@article{fdi:010085504,
  title = {{V}irologic failure and human immunodeficiency virus drug resistance in rural {C}ameroon with regard to the {UNAIDS} 90-90-90 treatment targets},
  author = {{B}oull{\'e}, {C}. and {G}uichet, {E}. and {K}ouanfack, {C}. and {A}ghokeng {F}obang, {A}velin and {O}nambany, {B}. and {I}kaka, {C}.{M}. and {N}gock, {E}. and {T}soumsta, {L}. and {M}sellati, {P}hilippe and {M}poudi-{N}gol{\'e}, {E}. and {P}eeters, {M}artine and {D}elaporte, {E}. and {L}aurent, {C}hristian},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {I}n rural {A}frica, data on virologic effectiveness of antiretroviral treatment ({ART}) are not sufficient to assess the gap with the {UNAIDS} 90-90-90 treatment targets. {W}e investigated the prevalences of unsuppressed viral load and antiretroviral drug resistance and the profile of genotypic resistance mutations among patients routinely treated in rural {C}ameroon. {M}ethods. {A} cross-sectional study was performed in 2013-2014 among patients sup or eq. 15 years and on first-line {ART} for sup. or eq. 6 months in a district hospital. {P}atients were offered free access to human immunodeficiency virus viral load testing. {G}enotypic drug resistance testing was done when the viral load was >1000 copies/m{L}. {M}ultivariate logistic regression models were used to assess the relation-ship of unsuppressed viral load or antiretroviral drug resistance with sociodemographic and medical characteristics. {R}esults. {O}f 407 patients (women 74.9%, median age 41.8 years, median time on {ART} 29.2 months), 96 (23.6%; 95% confidence interval [{CI}], 19.5-28.0) had unsuppressed viral load and 74 (18.2%; 95% {CI}, 14.6-22.3) had antiretroviral drug resistance. {T}he prevalences of unsuppressed viral load and resistance increased with time on {ART}, from 12.0% and 8.0% in the 6- to 12-month group to 31.3% and 27.1% in the >72-month group, respectively. {A}ll 74 patients with antiretroviral drug resistance were resistant to nonnucleoside reverse-transcriptase inhibitors, and 57 of them were also resistant to nucleoside reverse-transcriptase inhibitors. {C}onclusions. {O}ur estimations were among the highest observed in the west and central {A}frican region. {T}he proportion of patients with virologic failure should be divided at least by 2 to reach the {UNAIDS} 90-90-90 treatment targets.},
  keywords = {{CAMEROUN}},
  booktitle = {},
  journal = {{O}pen {F}orum {I}nfectious {D}iseases},
  volume = {3},
  numero = {4},
  pages = {ofw233 [7 ]},
  ISSN = {2328-8957},
  year = {2016},
  DOI = {10.1093/ofid/ofw233},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085504},
}