@article{fdi:010085385,
  title = {{APOL}1 renal risk variants and kidney function in {HIV}-1-infected people from {S}ub-{S}aharan {A}frica},
  author = {{K}abore, {N}. {F}. and {C}ournil, {A}mandine and {P}oda, {A}. and {C}iaffi, {L}. and {B}inns-{R}oemer, {E}. and {D}avid, {V}. and {E}ymard-{D}uvernay, {S}abrina and {Z}oungrana, {J}. and {S}emde, {A}. and {S}awadogo, {A}. {B}. and {K}oulla-{S}hiro, {S}. and {K}ouanfack, {C}. and {N}gom-{G}ueye, {N}. {F}. and {M}eda, {N}. and {W}inkler, {C}. and {L}imou, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction: {APOL}1 {G}1 and {G}2 alleles have been associated with kidney-related outcomes in people living with {HIV} ({PLHIV}) of {B}lack {A}frican origin. {N}o {APOL}1-related kidney risk data have yet been reported in {PLHIV} in {W}est {A}frica, where high {APOL}1 allele frequencies have been observed. {M}ethods: {W}e collected clinical data from {PLHIV} followed in {B}urkina {F}aso ({N}= 413) and in the {ANRS}-12169/2{LADY} trial ({C}ameroon, {S}enegal, {B}urkina {F}aso, {N} = 369). {APOL}1 {G}1 and {G}2 risk variants were genotyped using {T}ag{M}an assays, and {APOL}1 high-risk ({HR}) genotype was defined by the carriage of 2 risk alleles. {R}esults: {I}n {W}est {A}frica ({B}urkina {F}aso and {S}enegal), the {G}1 and {G}2 allele frequencies were 13.3% and 10.7%, respectively. {I}n {C}ameroon ({C}entral {A}frica), {G}1 and {G}2 frequencies were 8.7% and 8.9%, respectively. {APOL}1 {HR} prevalence was 4.9% in {W}est {A}frica and 3.4% in {C}ameroon. {W}e found no direct association between {APOL}1 {HR} and estimated glomerular filtration rate (e{GFR}) change over time. {N}evertheless, among the 2{LADY} cohort participants, those with both {APOL}1 {HR} and high baseline viral load had a faster e{GFR} progression (beta = -3.9[-7.7 to -0.1] ml/min per 1.73 m(2) per year, {P} < 0.05) than those with low-risk ({LR}) genotype and low viral load. {C}onclusion: {O}verall, the {APOL}1 risk allele frequencies in {PLHIV} were higher in the {W}est {A}frican countries than in {C}ameroon, but much lower than previously reported in some {N}igeria ethnic groups, which strongly advocates for further investigation in the {A}frican continent. {T}his study suggested that the virological status could modulate the {APOL}1 impact on kidney function, hence reinforcing the need for early therapeutic interventions.},
  keywords = {{A}frica ; {APOL}1 ; {B}urkina {F}aso ; e{GFR} ; {HIV} ; {K}idney risk ; {AFRIQUE} {SUBSAHARIENNE} ; {CAMEROUN} ; {SENEGAL} ; {BURKINA} {FASO}},
  booktitle = {},
  journal = {{K}idney {I}nternational {R}eports},
  volume = {7},
  numero = {3},
  pages = {483--493},
  ISSN = {2468-0249},
  year = {2022},
  DOI = {10.1016/j.ekir.2021.10.009},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085385},
}