@article{fdi:010085282,
  title = {{P}lasmodium falciparum coinfection is associated with improved {I}g{E} and {I}g{G}3 response against hookworm antigens},
  author = {{S}akyi, {S}. {A}. and {W}ilson, {M}. {D}. and {A}du, {B}. and {O}poku, {S}. and {B}rewoo, {A}. and {L}arbi, {A}. and {B}aafour, {E}. {K}. and {T}chum, {S}. {K}. and {S}aahene, {R}. {O}. and {A}niagyei, {W}. and {S}ewor, {C}. and {C}ourtin, {D}avid and {C}appello, {M}. and {G}yan, {B}. and {A}moani, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {P}lasmodium falciparum and {H}ookworm infections are prevalent in {W}est {A}frica and they cause iron deficiency anemia and protein malnutrition in {C}hildren. {I}mmune response of these parasites interact and their interactions could have repercussions on vaccine development and efficacy. {T}he current goal of hookworm eradication lies on vaccination. {W}e evaluated the effect of {P}. falciparum coinfection and albendazole treatment on naturally acquired antibody profile against hookworm {L}3 stage larvae antigen. {M}ethods {I}n a longitudinal study, 40 individuals infected with {N}ecator americanus only, 63 participants infected with {N}. americanus and {P}. falciparum, and 36 nonendemic controls ({NEC}s) were recruited. {T}he study was done in the {K}intampo {N}orth {M}etropolis of {G}hana. {S}tool and blood samples were taken for laboratory analyses. {S}erum samples were obtained before hookworm treatment and 3 weeks after treatment. {R}esults {T}he malaria-hookworm ({N}. americanus and {P}. falciparum) coinfected subjects had significantly higher levels of {I}g{E} (beta = 0.30, 95% {CI} = [0.12, 0.48], p = 0.023) and {I}g{G}3 (beta = 0.15, 95% {CI} = [0.02, 0.52], p = 0.004) compared to those infected with hookworm only ({N}. americanus). {T}he {N}. americanus groups had significantly higher levels of {I}g{G}3 (beta = 0.39, 95% {CI} = [0.14-0.62], p = 0.002) compared to the control group. {S}imilarly, {N}. americanus and {P}. falciparum coinfected participants had significantly higher levels of {I}g{E} (beta = 0.35, 95% {CI} = [0.70-0.39], p = 0.002) and {I}g{G}3 (beta = 0.54, 95% {CI} = [0.22-0.76], p = 0.002). {M}oreover, albendazole treatment led to a significant reduction in {I}g{E}, {I}g{A}, {I}g{M}, and {I}g{G}3 antibodies against hookworm {L}3 stage larvae (p < 0.05) {C}onclusion {P}. falciparum is associated with improved {I}g{E} and {I}g{G} response against hookworm {L}3 stage larvae. {T}reatment with single dose of albendazole led to reduction in naturally acquired immune response against hookworm infection. {T}hus, {P}. falciparum infection may have a boosting effect on hookworm vaccine effectiveness.},
  keywords = {coinfection ; hookworm infection ; immune response ; malaria parasite ; parasite antigens ; {GHANA}},
  booktitle = {},
  journal = {{H}ealth {S}cience {R}eports},
  volume = {5},
  numero = {4},
  pages = {e672 [10 p.]},
  year = {2022},
  DOI = {10.1002/hsr2.672},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085282},
}