@article{fdi:010085220,
  title = {{D}ifferential immunomodulatory effects of six pesticides of different chemical classes on human monocyte-derived macrophage functions},
  author = {{P}arny, {M}. and {C}oste, {A}. and {A}ubouy, {A}gn{\`e}s and {R}ahabi, {M}. and {P}rat, {M}. and {P}ipy, {B}. and {T}reilhou, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{E}xposure to pesticides through eyes, skin, ingestion and inhalation may affects human health by interfering with immune cells, such as macrophages. {W}e evaluated, in vitro, the effect of six pesticides widely used in apple arboriculture on the functions of human monocyte-derived macrophages (h{MDM}s). h{MDM}s were cultured for 4 or 24 h with or without pesticides (0.01, 0.1, 1, 10 mu mol.{L}-1). {W}e showed that chlorpyrifos, thiacloprid, thiophanate, boscalid, and captan had little toxic effect at the tested concentrations, while dithianon had lowcytotoxicity at 10 mu mol.{L}- 1. {W}hile boscalid showed no effect on h{MDM}s function, thiophanate (0.01 mu mol. {L}-1) stimulated with {TPA} and thiacloprid (1, 10 mu mol.{L}- 1) stimulated with zymosan activated {ROS} production. {C}hlorpyrifos, dithianon, and captan inhibited {ROS} production and {TNF}-alpha, {IL}-1{I}3 pro-inflammatory cytokines. {W}e established that dithianon (0.01-1 mu mol.{L}- 1) and captan (0.1, 1 mu mol.{L}- 1) induced m{RNA} expression of {NQO}1 and {HMOX}1 antioxidant enzymes. {D}ithianon also induced the m{RNA} expression of catalase, superoxide dismutase-2 at 10 mu mol.{L}- 1. {T}ogether, these results show that exposure to chlorpyrifos, dithianon, and captan induce immunomodulatory effects that may influence the disease fighting properties of monocytes/macrophages while pesticides such as thiacloprid, thiophanate and boscalid have little influence.},
  keywords = {{M}acrophages ; {O}xidative burst ; {C}ytokines ; {A}ntioxidant molecules ; {P}esticides},
  booktitle = {},
  journal = {{F}ood and {C}hemical {T}oxicology},
  volume = {163},
  numero = {},
  pages = {112992 [12 p.]},
  ISSN = {0278-6915},
  year = {2022},
  DOI = {10.1016/j.fct.2022.112992},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085220},
}