@article{fdi:010085215, title = {{S}urvival after curative pancreaticoduodenectomy for ampullary adenocarcinoma in a {S}outh {A}merican population : a retrospective cohort study}, author = {{F}ernandez-{P}lacencia, {R}. {M}. and {M}ontenegro, {P}. and {G}uerrero, {M}. and {S}errano, {M}. and {O}rtega, {E}. and {B}ravo, {M}. and {H}uanca, {L}. and {B}ertani, {S}t{\'e}phane and {T}rejo, {J}. {M}. and {W}ebb, {P}. and {M}alca-{V}asquez, {J}. and {T}axa, {L}. and {L}achos-{D}avila, {A}. and {C}elis-{Z}apata, {J}. and {L}uque-{V}asquez, {C}. and {P}ayet, {E}. and {R}uiz, {E}. and {B}errospi, {F}.}, editor = {}, language = {{ENG}}, abstract = {{BACKGROUND} {A}mpullary adenocarcinoma ({AAC}) is a rare neoplasm that accounts for only 0.2% of all gastrointestinal cancers. {I}ts incidence rate is lower than 6 cases per million people. {D}ifferent prognostic factors have been described for {AAC} and are associated with a wide range of survival rates. {H}owever, these studies have been exclusively conducted in patients originating from {A}sian, {E}uropean, and {N}orth {A}merican countries. {AIM} {T}o evaluate the histopathologic predictors of overall survival ({OS}) in {S}outh {A}merican patients with {AAC} treated with curative pancreaticoduodenectomy ({PD}). {METHODS} {W}e analyzed retrospective data from 83 {AAC} patients who underwent curative ({R}0) {PD} at the {N}ational {C}ancer {I}nstitute of {P}eru between {J}anuary 2010 and {O}ctober 2020 to identify histopathologic predictors of {OS}. {RESULTS} {S}ixty-nine percent of patients had developed intestinal-type {AAC} (69%), 23% had pancreatobiliary-type {AAC}, and 8% had other subtypes. {F}orty-one percent of patients were classified as {S}tage {I}, according to the {AJCC} 8th {E}dition. {R}ecurrence occurred primarily in the liver (n = 8), peritoneum (n = 4), and lung (n = 4). {S}tatistical analyses indicated that {T}3 tumour stage [hazard ratio ({HR}) of 6.4, 95% confidence interval ({CI}) of 2.5-16.3, {P} < 0.001], lymph node metastasis ({HR}: 4.5, 95%{CI}: 1.8-11.3, {P} = 0.001), and pancreatobiliary type ({HR}: 2.7, 95%{CI}: 1.2-6.2, {P} = 0.025) were independent predictors of {OS}. {CONCLUSION} {E}xtended tumour stage ({T}3), pancreatobiliary type, and positive lymph node metastasis represent independent predictors of a lower {OS} rate in {S}outh {A}merican {AAC} patients who underwent curative {PD}.}, keywords = {{G}astrointestinal neoplasms ; {A}denocarcinoma ; {A}mpulla ; {P}ancreaticoduodenectomy ; {S}urvival ; {S}outh {A}merica ; {PEROU}}, booktitle = {}, journal = {{W}orld {J}ournal of {G}astrointestinal {S}urgery}, volume = {14}, numero = {1}, pages = {24--35}, ISSN = {1948-9366}, year = {2022}, DOI = {10.4240/wjgs.v14.i1.24}, URL = {https://www.documentation.ird.fr/hor/fdi:010085215}, }