@article{fdi:010085209,
  title = {{A}ssessing fetal growth in {A}frica : application of the international {WHO} and {INTERGROWTH}-21st standards in a {B}eninese pregnancy cohort},
  author = {{Y}ovo, {E}. and {A}ccrombessi, {M}. and {A}gbota, {G}ino and {H}ocquette, {A}. and {A}tade, {W}. and {L}adikpo, {O}. {T}. and {M}ehoba, {M}. and {D}egbe, {A}. and {M}ombo-{N}goma, {G}. and {M}assougbodji, {A}. and {J}ackson, {N}. and {F}ievet, {N}adine and {H}eude, {B}. and {Z}eitlin, {J}. and {B}riand, {V}al{\'e}rie},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {F}etal growth restriction is a major complication of pregnancy and is associated with stillbirth, infant death and child morbidity. {U}ltrasound monitoring of pregnancy is becoming more common in {A}frica for fetal growth monitoring in clinical care and research, but many countries have no national growth charts. {W}e evaluated the new international fetal growth standards from {INTERGROWTH}-21st and {WHO} in a cohort from southern {B}enin. {M}ethods {R}epeated ultrasound and clinical data were collected in women from the preconceptional {RECIPAL} cohort (241 women with singleton pregnancies, 964 ultrasounds). {W}e modelled fetal biometric parameters including abdominal circumference ({AC}) and estimated fetal weight ({EFW}) and compared centiles to {INTERGROWTH}-21st and {WHO} standards, using the {B}land and {A}ltman method to assess agreement. {F}or {EFW}, we used {INTERGROWTH}-21st standards based on their {EFW} formula ({IG}21st) as well as a recent update using {H}adlock's {EFW} formula ({IG}21hl). {P}roportions of fetuses with measurements under the 10th percentile were compared. {R}esults {M}aternal malaria and anaemia prevalence was 43% and 69% respectively and 11% of women were primigravid. {O}verall, the centiles in the {RECIPAL} cohort were higher than that of {INTERGROWTH}-21st and closer to that of {WHO}. {C}onsequently, the proportion of fetuses under 10th percentile thresholds was systematically lower when applying {IG}21st compared to {WHO} standards. {A}t 27-31 weeks and 33-38 weeks, respectively, 7.4% and 5.6% of fetuses had {EFW} <10th percentile using {IG}21hl standards versus 10.7% and 11.6% using {WHO} standards. {C}onclusion {D}espite high anemia and malaria prevalence in the cohort, {IG}21st and {WHO} standards did not identify higher than expected proportions of fetuses under the 10th percentiles of ultrasound parameters or {EFW}. {T}he proportions of fetuses under the 10th percentile threshold for {IG}21st charts were particularly low, raising questions about its use to identify growth-restricted fetuses in {A}frica.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{PL}o{S} {O}ne},
  volume = {17},
  numero = {1},
  pages = {e0262760 [17 p.]},
  ISSN = {1932-6203},
  year = {2022},
  DOI = {10.1371/journal.pone.0262760},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085209},
}