@article{fdi:010085168,
  title = {{I}nfluence of host-related factors and exposure to mosquito bites on the dynamics of antibody response to {P}lasmodium falciparum antigens},
  author = {{A}ka, {K}. {G}. and {Y}ao, {S}. {S}. and {G}bessi, {E}. {A}. and {A}dja, {A}. {M}. and {C}orbel, {V}incent and {K}offi, {A}. {A}. and {R}ogier, {C}. and {A}ssi, {S}. {B}. and {T}oure, {O}. {A}. and {R}emou{\'e}, {F}ranck and {P}oinsignon, {A}nne},
  editor = {},
  language = {{ENG}},
  abstract = {{H}umoral immunity to {P}lasmodium falciparum is acquired after repeated infections, and can lead to clinical protection. {T}his study aimed to evaluate how human-, parasite-, and environment-related determinants can modulate the dynamics of {I}g{G} responses to {P}lasmodium falciparum after an infection. {I}ndividuals (n = 68, average age = 8.2 years) with uncomplicated malaria were treated with {ACT} and followed up for 42 days. {I}g{G} responses to {P}. falciparum merozoite antigens ({P}f{MSP}1, {P}f{MSP}3, {P}f{AMA}1, {P}f{GLURP}-{R}0), to whole schizont extract ({P}f{S}chz), and to {A}nopheles g{SG}6-{P}1 and {A}edes {N}term-34 k{D}a salivary peptides were measured. {R}egression analyses were used to identify factors that influence the dynamics of {I}g{G} response to {P}. falciparum antigen between {D}0 and {D}42, including demographic and biological factors and the level of exposure to mosquito bites. {T}he dynamics of {I}g{G} response to {P}. falciparum differed according to the antigen. {A}ccording to multivariate analysis, {I}g{G} responses to {P}f{S}chz and to {P}f{GLURP}-{R}0 appear to be affected by exposure to {A}edes saliva and are associated with age, parasite density, and anti {P}lasmodium pre-existing immune response at study inclusion. {T}he present work shows that human exposure to {A}edes saliva may contribute, in addition to other factors, to the regulation of anti {P}lasmodium immune responses during a natural infection.},
  keywords = {{P}lasmodium falciparum ; malaria ; {A}nopheles ; {A}edes ; humoral acquired ; immunity ; saliva ; immunomodulation ; exposure ; {COTE} {D}'{IVOIRE} ; {BOUAKE} ; {ZONE} {TROPICALE}},
  booktitle = {},
  journal = {{T}ropical {M}edicine and {I}nfectious {D}isease},
  volume = {6},
  numero = {4},
  pages = {185 [17 p.]},
  year = {2021},
  DOI = {10.3390/tropicalmed6040185},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085168},
}