@article{fdi:010085137,
  title = {{N}ew insights and advances on pyomelanin production : from microbial synthesis to applications},
  author = {{L}orquin, {F}. and {P}iccerelle, {P}. and {O}rneto, {C}. and {R}obin, {M}. and {L}orquin, {J}ean},
  editor = {},
  language = {{ENG}},
  abstract = {{P}yomelanin is a brown-black phenolic polymer and results from the oxidation of homogentisic acid ({HGA}) in the {L}-tyrosine pathway. {A}s part of the research for natural and active ingredients issued from realistic bioprocesses, this work re-evaluates the {HGA} pigment and makes an updated inventory of its syntheses, microbial pathways, and properties, with tracks and recent advances for its large-scale production. {T}he mechanism of the {HGA} polymerization is also well documented. {I}n alkaptonuria, pyomelanin formation leads to connective tissue damage and arthritis, most probably due to the {ROS} issued from {HGA} oxidation. {W}hile {UV} radiation on human melanin may generate degradation products, pyomelanin is not photodegradable, is hyperthermostable, and has other properties better than {L}-{D}opa melanin. {T}his review aims to raise awareness about the potential of this pigment for various applications, not only for skin coloring and protection but also for other cells, materials, and as a promising (semi)conductor for bioelectronics and energy.},
  keywords = {{P}yomelanin ; {P}olymerization ; {H}ydroxylase ; {L}accases ; {A}pplications},
  booktitle = {},
  journal = {{J}ournal of {I}ndustrial {M}icrobiology and {B}iotechnology},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[20 ]},
  ISSN = {1367-5435},
  year = {2022},
  DOI = {10.1093/jimb/kuac013},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085137},
}