@article{fdi:010085070,
  title = {{P}opulation diversity of antibiotic resistant enterobacterales in samples from wildlife origin in {S}enegal : identification of a multidrug resistance transposon carrying bla({CTX}-{M}-15) in {E}scherichia coli},
  author = {{A}bdallah, {R}. and {Y}imagou, {E}. {K}. and {H}adjadj, {L}. and {M}ediannikov, {O}leg and {I}brahim, {A}. and {D}avoust, {B}. and {B}arciela, {A}. and {H}ernandez-{A}guilar, {R}. {A}. and {D}iatta, {G}eorges and {S}okhna, {C}heikh and {R}aoult, {D}. and {R}olain, {J}. {M}. and {B}aron, {S}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction{T}he role of wildlife in the transmission of antimicrobial resistant ({AMR}) is suspected but scarcely reported in current studies. {T}herefore, we studied the dynamics and prevalence of antibiotic-resistant {E}nterobacterales in antibiotic-limited areas of {S}enegal. {M}aterials and {M}ethods{W}e collected fecal samples from monkeys and apes ({N} = 226) and non-fecal environmental samples ({N} = 113) from {S}enegal in 2015 and 2019. {W}e grew the samples on selective media, subsequently isolated {AMR} {E}nterobacterales, and then sequenced their genomes. {R}esults{W}e isolated 72 different {E}nterobacterales among which we obtained a resistance rate of 65% for colistin ({N} = 47/72) and 29% for third generation-cephalosporin ({C}3{G}) (29%, {N} = 21/72). {I}nterestingly, almost 46% of our isolates, among {E}nterobacter sp., {C}itrobacter cronae and {K}lebsiella aerogenes, belong to 34 new {ST}s. {M}oreover, the genes bla({CTX}-{M}-15), bla({TEM}1{B}), sul2, dfr{A}14, qnrs, aph(3 '), aph(6), tet{A}, and tet{R} harbored within a transposon on the {I}nc{Y} plasmid of {ST}224 {E}scherichia coli were transferred and inserted into a {ST}10 {E}. coli phage coding region. {C}onclusion{W}ildlife constitutes a rich, unexplored reservoir of natural microbial diversity, {AMR} genes and international resistant clones pathogenic in humans. {T}he presence of a transposon that carries {AMR} genes is intriguing since no antibiotics are used in the non-human primates we studied.},
  keywords = {antibiotic resistance ; {E}nterobacterales ; primates ; environment ; {S}enegal ; {SENEGAL}},
  booktitle = {},
  journal = {{F}rontiers in {M}icrobiology},
  volume = {13},
  numero = {},
  pages = {838392 [12 ]},
  year = {2022},
  DOI = {10.3389/fmicb.2022.838392},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085070},
}