@article{fdi:010084992,
  title = {{P}lacental malaria, maternal {HIV} infection and infant morbidity},
  author = {{B}riand, {V}al{\'e}rie and {B}adaut, {C}yril and {C}ot, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{C}o-infection with malaria and {HIV} in pregnant women is particularly common in sub-{S}aharan {A}frica and has serious consequences for both mother and newborn child. {N}umerous studies have been published on the effects in pregnancy of {HIV} on malaria infection and on the effects of malaria on {HIV} infection. {T}he increased prevalence and intensity of parasitaemia (placental and peripheral infection and parasite density) in {HIV}-infected women is well established. {S}imilarly, malaria infection seems to be associated with higher viral loads. {H}owever, there is still uncertainty as to the influence of malaria on the clinical course of {HIV} infection, mother-to-child transmission of {HIV}, and the consequences of co-infection on post-neonatal infant morbidity and mortality. {T}hese questions require further investigation. {I}n terms of prevention, intermittent preventive treatment with two doses of sulfadoxine-pyrimethamine ({SP}) has been found less effective in preventing malaria in {HIV}- infected than uninfected women, and a higher dosage (such as monthly ({SP}) has been recommended. {R}egarding malaria, there is also a lack of clear recommendations for women taking daily cotrimoxazole prophylaxis, and anti-malarial-antiretroviral interactions are not well understood. {M}ulti-centre clinical trials should be undertaken to investigate effective, coherent and well-tolerated strategies to prevent malaria in {HIV}- infected women. {S}afe alternatives to {SP} should be identified and evaluated rapidly. {F}inally, a central pharmaco-vigilance network should be instituted to report adverse effects.},
  keywords = {},
  booktitle = {},
  journal = {{A}nnals of {T}ropical {P}aediatrics},
  volume = {29},
  numero = {2},
  pages = {71--83},
  ISSN = {0272-4936},
  year = {2009},
  DOI = {10.1179/146532809x440699},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084992},
}