Bel Lassen P. auteur aut IRD Charlotte F. auteur aut IRD Liu Y. auteur aut IRD Bedossa P. auteur aut IRD Le Naour G. auteur aut IRD Tordjman J. auteur aut IRD Poitou C. auteur aut IRD Bouillot J. L. auteur aut IRD Genser L. auteur aut IRD Zucker Jean-Daniel auteur aut IRD Sokolovska N. auteur aut IRD Aron-Wisnewsky J. auteur aut IRD Clement K. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Context: Bariatric surgery (BS) induces major and sustainable weight loss in many patients. Factors predicting poor weight-loss response (PR) need to be identified to improve patient care. Quantification of subcutaneous adipose tissue (scAT) fibrosis is negatively associated with post-BS weight loss, but whether it could constitute a predictor applicable in clinical routine remains to be demonstrated. Objective: To create a semiquantitative score evaluating scAT fibrosis and test its predictive value on weight-loss response after Roux-en-Y gastric bypass (RYGB). Methods: We created a fibrosis score of adipose tissue (FAT score) integrating perilobular and pericellular fibrosis. Using this score, we characterized 183 perioperative scAT biopsy specimens from severely obese patients who underwent RYGB (n = 85 from a training cohort; n = 98 from a confirmation cohort). PR to RYGB was defined as <28% of total weight loss at 1 year (lowest tertile). The link between FAT score and PR was tested in univariate and multivariate models. Results: FAT score was directly associated with increasing scAT fibrosis measured by a standard quantification method (P for trend <0.001). FAT score interobserver agreement was good (kappa = 0.76). FAT score >= 2 was significantly associated with PR. The association remained significant after adjustment for age, diabetes status, hypertension, percent fat mass, and interleukin-6 level (adjusted odds ratio, 3.6; 95% confidence interval, 1.8 to 7.2; P = 0.003). Conclusions: The FAT score is a new, simple, semiquantitative evaluation of human scAT fibrosis that may help identify patients with a potential limited weight-loss response to RYGB. specialized 050 054 102 7 2443-2453 2017 0021-972X https://www.documentation.ird.fr/hor/fdi:010084988 10.1210/jc.2017-00138 0021-972X [F B010084988] https://www.documentation.ird.fr/hor/fdi:010084988 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2023-06/010084988.pdf IRD - Base Horizon / Pleins textes 2017-09-05 2023-07-11 fdi:010084988 fre