@article{fdi:010084771,
  title = {{T}ranscriptome analysis of {P}lasmodium falciparum isolates from {B}enin reveals specific gene expression associated with cerebral malaria},
  author = {{G}uillochon, {E}. and {F}raering, {J}eremy and {J}oste, {V}. and {K}amaliddin, {C}. and {V}ianou, {B}. and {H}ouze, {L}udivine and {B}audrin, {L}. {G}. and {F}aucher, {J}. {F}. and {A}ubouy, {A}gn{\`e}s and {H}ouze, {S}. and {C}ot, {M}ichel and {A}rgy, {N}. and {T}aboureau, {O}. and {B}ertin, {G}wladys {I}. and {N}euro, {C}. {M}. {G}rp},
  editor = {},
  language = {{ENG}},
  abstract = {{C}erebral malaria ({CM}) is the severest form of {P}lasmodium falciparum infection. {C}hildren under 5 years old are those most vulnerable to {CM}, and they consequently have the highest risk of malaria-related death. {P}arasite-associated factors leading to {CM} are not yet fully elucidated. {W}e therefore sought to characterize the gene expression profile associated with {CM}, using {RNA} sequencing data from 15 {CM} and 15 uncomplicated malaria isolates from {B}enin. {C}erebral malaria parasites displayed reduced circulation times, possibly related to higher cytoadherence capacity. {C}onsistent with the latter, we detected increased var genes abundance in {CM} isolates. {D}ifferential expression analyses showed that distinct transcriptome profiles are signatures of malaria severity. {G}enes involved in adhesion, excluding variant surface antigens, were dysregulated, supporting the idea of increased cytoadhesion capacity of {CM} parasites. {F}inally, we found dysregulated expression of genes in the entry into host pathway that may reflect greater erythrocyte invasion capacity of {CM} parasites.},
  keywords = {cerebral malaria ; cytoadherence ; {P}lasmodium falciparum ; transcriptomics ; var genes ; {BENIN}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[10 ]},
  ISSN = {0022-1899},
  year = {2022},
  DOI = {10.1093/infdis/jiac086},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084771},
}