@article{fdi:010084711,
  title = {{A}n ancient truncated duplication of the anti-{M}ullerian hormone receptor type 2 gene is a potential conserved master sex determinant in the {P}angasiidae catfish family},
  author = {{W}en, {M}. and {P}an, {Q}. {W}. and {J}ouanno, {E}. and {M}ontfort, {J}. and {Z}ahm, {M}. and {C}abau, {C}. and {K}lopp, {C}. and {I}ampietro, {C}. and {R}oques, {C}. and {B}ouchez, {O}. and {C}astinel, {A}. and {D}onnadieu, {C}. and {P}arrinello, {H}. and {P}oncet, {C}. and {B}elmonte, {E}. and {G}autier, {V}. and {A}varre, {J}ean-{C}hristophe and {D}ugu{\'e}, {R}{\'e}mi and {G}ustiano, {R}. and {H}a, {T}. {T}. {T}. and {C}ampet, {M}. and {S}riphairoj, {K}. and {R}ibolli, {J}. and de {A}lmeida, {F}. {L}. and {D}esvignes, {T}. and {P}ostlethwait, {J}. {H}. and {B}ucao, {C}. {F}. and {R}obinson-{R}echavi, {M}. and {B}obe, {J}. and {H}erpin, {A}. and {G}uiguen, {Y}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he evolution of sex determination ({SD}) in teleosts is amazingly dynamic, as reflected by the variety of different master sex-determining genes identified. {P}angasiids are economically important catfishes in {S}outh {A}sian countries, but little is known about their {SD} system. {H}ere, we generated novel genomic resources for 12 {P}angasiids and characterized their {SD} system. {B}ased on a {P}angasianocion hypophthalmus chromosome-scale genome assembly, we identified an anti-{M}ullerian hormone receptor type {II} gene (amhr2) duplication, which was further characterized as being sex-linked in males and expressed only in testes. {T}hese results point to a {Y} chromosome male-specific duplication (amhr2by) of the autosomal amhr2a. {S}equence annotation revealed that the {P}. hypophthalmus {A}mhr2by is truncated in its {N}-terminal domain, lacking the cysteine-rich extracellular part of the receptor that is crucial for ligand binding, suggesting a potential route for its neofunctionalization. {R}eference-guided assembly of 11 additional {P}angasiids, along with sex-linkage studies, revealed that this truncated amhr2 by duplication is a male-specific conserved gene in {P}angasiids. {R}econstructions of the amhr2 phylogeny suggested that amhr2by arose from an ancient duplication/insertion event at the root of the {S}iluroidei radiation that is dated to similar to 100 million years ago. {T}ogether these results bring multiple lines of evidence supporting that amhr2by is an ancient and conserved master sex-determining gene in {P}angasiids, a finding that highlights the recurrent use of the transforming growth factor beta pathway, which is often used for the recruitment of teleost master {SD} genes, and provides another empirical case towards firther understanding of dynamics of {SD} systems.},
  keywords = {amhr2 ; evolution ; male genome assembly ; pangasiid catfishes ; sex determination},
  booktitle = {},
  journal = {{M}olecular {E}cology {R}esources},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[18 p.]},
  ISSN = {1755-098{X}},
  year = {2022},
  DOI = {10.1111/1755-0998.13620},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084711},
}