@article{fdi:010084703,
  title = {{S}eroprevalence of {I}g{G} antibodies against multiple arboviruses in bats from {C}ameroon, {G}uinea, and the {D}emocratic {R}epublic of {C}ongo},
  author = {{R}aulino, {R}. and {T}haurignac, {G}. and {K}eita, {A}. {K}. and {E}steban, {A}mandine and {G}oumou, {S}. and {D}iallo, {R}. and {N}dimbo-{K}umugo, {S}. {P}. and {B}ass, {I}. {N}. and {K}ingebeni, {P}. {M}. and {T}oure, {A}. and {D}elaporte, {E}. and {A}huka-{M}undeke, {S}. and {T}amfum, {J}. {J}. {M}. and {M}poudi-{N}gole, {E}. and {P}eeters, {M}artine and {A}youba, {A}hidjo},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {E}mergence of mosquito-borne arboviruses has caused significant public health burden. {T}he life cycle of arboviruses comprises sylvatic and urban cycles, including a wildlife reservoir, a human host, and an arthropod vector. {H}owever, many questions remain on the sylvatic cycles of arboviruses. {I}n this study, we investigate the prevalence of {I}g{G} antibodies to arboviruses of public health importance in {A}frican bats.{M}aterial and {M}ethods: {W}e collected dried blood spots from bats in {C}ameroon, {G}uinea, and the {D}emocratic {R}epublic of the {C}ongo ({DRC}). {T}o detect {I}g{G} antibodies to 10 antigens of 6 arboviruses ({D}engue, {Z}ika, {W}est {N}ile, {U}sutu, {C}hikungunya, and {O}'nyong nyong viruses), we adapted a previously validated multiplex detection assay based on the {L}uminex technology.{R}esults: {W}e tested samples from 2579 bats, representing 1917 frugivorous and 641 insectivorous bats distributed in 7 families and 21 species. {O}verall, 218/2579 (8.45%) bat samples reacted with at least 1 of the 10 antigens tested. {T}he highest prevalence was observed against {U}sutu virus with 2.3% (59/2579), followed by 1.9% (49/2579) and 1.35% (35/2579) for the {D}engue virus serotypes 4 and 3, respectively. {T}he global seroprevalence varied by country and collection site: 11% (151/1376) in {C}ameroon, 3.5% (20/565) in {DRC}, and 7.3% (47/638) in {G}uinea. {T}he highest rates were observed in {H}ypsignathus monstrosus (17.9%), {R}ousettus aegyptiacus (16.4%), and {E}idolon helvum (10.7%), and in species from the insectivorous {M}olossidae family (7.8-8.9%). {F}inally, we observed changes in seroprevalence over the year in {E}. helvum and {H}. monstrosus colonies, which could be related to population structure.{C}onclusion: {O}n more than 2500 bat samples tested, we showed variable {I}g{G} seroprevalences against multiple arboviruses. {O}verall, the prevalence of {I}g{G} antibodies of 8.45% against arboviruses found in bats suggest that they could play a role in arboviruses cycles in the wild, in addition to other animal species.},
  keywords = {arboviruses ; bats ; {A}frica ; antibodies ; {L}uminex ; {CAMEROUN} ; {GUINEE} ; {REPUBLIQUE} {DEMOCRATIQUE} {DU} {CONGO}},
  booktitle = {},
  journal = {{V}ector-{B}orne and {Z}oonotic {D}iseases},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[11 p.]},
  ISSN = {1530-3667},
  year = {2022},
  DOI = {10.1089/vbz.2021.0076},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084703},
}