@article{fdi:010084640,
  title = {{Z}oonotic origin of the human malaria parasite {P}lasmodium malariae from {A}frican apes},
  author = {{P}lenderleith, {L}. {J}. and {L}iu, {W}. {M}. and {L}i, {Y}. {Y}. and {L}oy, {D}. {E}. and {M}ollison, {E}. and {C}onnell, {J}. and {A}youba, {A}hidjo and {E}steban, {A}mandine and {P}eeters, {M}artine and {S}anz, {C}. {M}. and {M}organ, {D}. {B}. and {W}olfe, {N}. {D}. and {U}lrich, {M}. and {S}achse, {A}. and {C}alvignac-{S}pencer, {S}. and {L}eendertz, {F}. {H}. and {S}haw, {G}. {M}. and {H}ahn, {B}. {H}. and {S}harp, {P}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he human parasite {P}lasmodium malariae has relatives infecting {A}frican apes ({P}lasmodium rodhaini) and {N}ew {W}orld monkeys ({P}lasmodium brasilianum), but its origins remain unknown. {U}sing a novel approach to characterise {P}. malariae-related sequences in wild and captive {A}frican apes, we found that this group comprises three distinct lineages, one of which represents a previously unknown, highly divergent species infecting chimpanzees, bonobos and gorillas across central {A}frica. {A} second ape-derived lineage is much more closely related to the third, human-infective lineage {P}. malariae, but exhibits little evidence of genetic exchange with it, and so likely represents a separate species. {M}oreover, the levels and nature of genetic polymorphisms in {P}. malariae indicate that it resulted from the zoonotic transmission of an {A}frican ape parasite, reminiscent of the origin of {P}. falciparum. {I}n contrast, {P}. brasilianum falls within the radiation of human {P}. malariae, and thus reflects a recent anthroponosis. {P}lasmodium malariae is a cause of malaria in humans and related species have been identified in non-human primates. {H}ere, the authors use genomic analyses to establish that human {P}. malariae arose from a host switch of an ape parasite whilst a species infecting {N}ew {W}orld monkeys can be traced to a reverse zoonosis.},
  keywords = {{AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {13},
  numero = {1},
  pages = {1868 [12 p.]},
  year = {2022},
  DOI = {10.1038/s41467-022-29306-4},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084640},
}