@article{fdi:010084603,
  title = {{ICAM}-1 ({K}ilifi) variant is not associated with cerebral and severe malaria pathogenesis in {B}eninese children},
  author = {{B}lankson, {S}. {O}. and {D}adje, {D}. {S}. and {T}raikia, {N}. and {A}lao, {M}. {J}. and {A}yivi, {S}. and {A}moussou, {A}. and {D}eloron, {P}hilippe and {T}uikue {N}dam, {N}icaise and {M}ilet, {J}acqueline and {B}asco, {L}eonardo and {A}niweh, {Y}. and {T}ahar, {R}achida},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {C}ytoadhesion and sequestration of {P}lasmodium falciparum infected red blood cells (i{RBC}) in the microvasculature of vital organs are a major cause of malaria pathology. {S}everal studies have provided evidence on the implication of the human host intercellular adhesion molecule-1 ({ICAM}-1) as a major receptor for i{RBC}s binding to {P}. falciparum erythrocyte membrane protein 1 ({P}f{EMP}1) in the development of severe and cerebral malaria. {T}he genetic polymorphism {K}29{M} in the immunoglobulin-like domain of {ICAM}-1, known as {ICAM}-1({K}ilifi), has been associated with either increased or decreased risk of developing cerebral malaria. {M}ethods {T}o provide more conclusive results, the genetic polymorphism of {ICAM}-1({K}ilifi) was assessed by {PCR} and sequencing in blood samples from 215 {B}eninese children who presented with either mild or severe malaria including cerebral malaria. {R}esults and conclusions {T}he results showed that in this cohort of {B}eninese children, the {ICAM}-1(kilifi) variant is present at the frequencies of 0.27, similar to the frequency observed in other {A}frican countries. {T}his {ICAM}-1(kilifi) variant was not associated with disease severity in agreement with other findings from the {G}ambia, {T}anzania, {M}alawi, {G}abon, and {T}hailand, suggesting no evidence of a direct link between this polymorphism and the pathogenesis of severe and cerebral malaria.},
  keywords = {{P}lasmodium falciparum ; {M}alaria ; cerebral malaria ; {P}olymorphism ; {ICAM}-1 ; {ICAM}-1(kilifi) ; {BENIN}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {21},
  numero = {1},
  pages = {115 [6 p.]},
  year = {2022},
  DOI = {10.1186/s12936-022-04139-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084603},
}