%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Nguyen, N. N.
%A Hoang, V.
%A Dao, T. L.
%A Meddeb, L.
%A Cortaredona, Sébastien
%A Lagier, J. C.
%A Million, M.
%A Raoult, D.
%A Gautret, P.
%T Long-term persistence of olfactory and gustatory disorders in COVID-19 patients
%D 2022
%L fdi:010084561
%G ENG
%J Frontiers in Medicine
%K SARS-CoV-2 ; COVID-19 ; smell ; taste ; persistence ; long COVID
%K FRANCE ; MARSEILLE
%M ISI:000770878700001
%P 794550 [11 ]
%R 10.3389/fmed.2022.794550
%U https://www.documentation.ird.fr/hor/fdi:010084561
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2022-05/010084561.pdf
%V 9
%W Horizon (IRD)
%X Smell and taste disorders are frequent symptoms during acute COVID-19 and may persist long after the resolution of the initial phase. This study aims to estimate the proportion and risk factors for smell and/or taste disorders at the onset of symptoms and their persistence after more than 6 months of follow-up in COVID-19 patients. We analyzed a prospective cohort of COVID-19 patients admitted to our institute in Marseille, France in early 2020. After being discharged from the hospital, patients with smell and/or taste disorders were contacted for a telephone interview. Logistic regression analysis was performed to determine the risk factors for smell and/or taste disorders. A total of 3,737 patients were included, of whom 1,676 reported smell and/or taste disorders at the onset of symptoms. Taste and/or smell disorders were independently associated with being younger and female, a lower likelihood of suffering from diabetes, cardiovascular diseases and cancer, a longer delay between the onset of symptoms and consultation, and non-severe forms of COVID-19 at admission. Of the 605 patients with smell and/or taste disorders who were followed-up, 154 (25.5%) reported the persistence of symptoms for more than 6 months. At the time of follow-up, being female, having a chronic respiratory disease and using angiotensin-converting enzyme inhibitors (ACEis) were factors independently associated with the persistence of smell and/or taste disorders. In conclusion, the long-term persistence of olfactory and gustative disorders is frequent among COVID-19 patients, notably affecting female patients and patients who suffered from chronic respiratory diseases before infection. The role of ACEis needs to be further evaluated in larger numbers of patients.
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