@article{fdi:010084502,
  title = {{T}he {SARS}-{C}o{V}-2 {A}lpha variant exhibits comparable fitness to the {D}614{G} strain in a {S}yrian hamster model},
  author = {{C}ochin, {M}. and {L}uciani, {L}. and {T}ouret, {F}. and {D}riouich, {J}. {S}. and {P}etit, {P}. {R}. and {M}oureau, {G}. and {B}aronti, {C}{\'e}cile and {L}aprie, {C}. and {T}hirion, {L}aurence and {M}aes, {P}. and {B}oudewijns, {R}. and {N}eyts, {J}. and {L}amballerie, {X}. de and {N}ougairede, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {SARS}-{C}o{V}-2 {A}lpha variant exhibits similar transmission dynamics to an ancestral {D}614{G} variant in a {S}yrian hamster model, suggesting the limitations of using the hamster as the sole model to assess differences between {SARS}-{C}o{V}-2 strains. {L}ate 2020, {SARS}-{C}o{V}-2 {A}lpha variant emerged in {U}nited {K}ingdom and gradually replaced {G}614 strains initially involved in the global spread of the pandemic. {I}n this study, we use a {S}yrian hamster model to compare a clinical strain of {A}lpha variant with an ancestral {G}614 strain. {T}he {A}lpha variant succeed to infect animals and to induce a pathology that mimics {COVID}-19. {H}owever, both strains replicate to almost the same level and induced a comparable disease and immune response. {A} slight fitness advantage is noted for the {G}614 strain during competition and transmission experiments. {T}hese data do not corroborate the epidemiological situation observed during the first half of 2021 in humans nor reports that showed a more rapid replication of {A}lpha variant in human reconstituted bronchial epithelium. {T}his study highlights the need to combine data from different laboratories using various animal models to decipher the biological properties of newly emerging {SARS}-{C}o{V}-2 variants.},
  keywords = {{SYRIE}},
  booktitle = {},
  journal = {{C}ommunications {B}iology},
  volume = {5},
  numero = {1},
  pages = {225 [8 p.]},
  year = {2022},
  DOI = {10.1038/s42003-022-03171-9},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084502},
}