@article{fdi:010084385,
  title = {{E}fficacy of care{HPV} ({TM}) human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with {HIV}-1 in {L}ao {P}eople's {D}emocratic {R}epublic},
  author = {{P}aboriboune, {P}. and {P}hongsavan, {K}. and {A}rounlangsy, {P}. and {F}laissier, {B}. and {A}phayarath, {O}. and {P}himmasone, {P}. and {B}anchongphanith, {K}. and {X}ayaovong, {M}. and {J}ourdain, {G}onzague and {S}chott, {A}. {M}. and {S}aadatian-{E}lahi, {M}. and {M}agaud, {L}. and {K}lich, {A}. and {N}go-{G}iang-{H}uong, {N}icole and {H}eard, {I}. and {R}abilloud, {M}. and {P}icot, {V}. {S}. and {L}onguet, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}n the {L}ao {P}eople's {D}emocratic {R}epublic ({L}ao {PDR}), cervical cancer is the third leading cause of women cancer. {A}ims: {T}he objective of this cross-sectional study was to compare the efficacy of care{HPV} ({TM}) test versus conventional {P}ap smear or {S}iriraj liquid-based cytology in the detection of cervical cancer in women living with human immunodeficiency virus type 1 ({HIV}-1). {M}aterials & {M}ethods: {O}verall, 631 women consented to participate. {F}our cervical specimens were taken for the purpose of conventional {P}ap smear, {S}iriraj liquid-based cytology, care{HPV} ({TM}) test, and {HPV}-16 genotyping. {T}he exact {M}c{N}emar test was used to compare the efficacy and diagnostic performance of the tests. {R}esults: {O}f the 631 women with follow-up, 331 were human papillomavirus ({HPV}) negative. {H}igh-grade squamous intraepithelial lesions were found in 37 women, biopsy-proven high-grade cervical intraepithelial neoplasia in 50 women, and invasive carcinoma in seven women. {T}he proportion of women with high-grade cervical lesion or carcinoma detected after abnormal care{HPV} ({TM}) test was higher (6.02%; 95% confidence interval [{CI}]: 4.4-8.1) than that detected by conventional {P}ap smear (4.59%; 95% {CI}: 3.2-6.5). care{HPV} ({TM}) and {HPV}-16 genotyping had, respectively, the highest sensitivity (80.8%; 95% {CI}: 67.4-89.5) and specificity (92.2%; 95% {CI}: 89.8-94.2). {HPV}-16 was the most frequently detected genotype. {C}onclusions: care{HPV} ({TM}) test represents a screening option in {L}ao {PDR}, particularly in women living with {HIV}-1 because of higher prevalence of chronic {HPV} in this population.},
  keywords = {care{HPV} ({TM}) ; cervical cancer ; {HIV}-1 ; {L}ao {PDR} ; liquid-based cytology ; {P}apanicolaou test ; {LAOS}},
  booktitle = {},
  journal = {{C}ancer {M}edicine},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[11 p.]},
  ISSN = {2045-7634},
  year = {2022},
  DOI = {10.1002/cam4.4502},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084385},
}