@article{fdi:010084350,
  title = {{S}pecific combinations of inflammatory, angiogenesis and vascular integrity biomarkers are associated with clinical severity, coma and mortality in {B}eninese children with {P}lasmodium falciparum malaria},
  author = {{T}ornyigah, {B}. and {B}lankson, {S}. {O}. and {A}damou, {R}. and {M}oussiliou, {A}. and {R}ietmeyer, {L}. and {T}ettey, {P}. and {D}ikroh, {L}. and {A}ddo, {B}. and {L}amptey, {H}. and {A}lao, {M}. {J}. and {A}moussou, {A}. and {P}adounou, {C}. and {R}oussilhon, {C}. and {P}ons, {S}. and {M}ensah, {B}. {A}. and {T}uikue {N}dam, {N}icaise and {T}ahar, {R}achida},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. {U}sing quantitative {ELISA}, we assessed the plasma concentrations of {P}rocalcitonin, {P}entraxine-3, {A}ng-2, s{T}ie-2, su{PAR}, s{EPCR} and s{ICAM}-1 in a cohort of {B}eninese children with malaria to investigate their potential association with clinical manifestations of malaria. {W}e found that all molecules showed higher levels in children with severe or cerebral malaria compared to those with uncomplicated malaria (p-value < 0.005). {P}lasma concentrations of {P}entraxine-3, {P}rocalcitonin, {A}ng-2 and the soluble receptors were significantly higher in children with coma as defined by a {B}lantyre {C}oma {S}core < 3 (p < 0.001 for {P}entraxine-3, su{PAR}, and s{T}ie-2, p = 0.004 for {PCT}, p = 0.005 for s{ICAM}-1, p = 0.04 for {A}ng-2). {M}oreover, except for the {PCT} level, the concentrations of {P}entraxine-3, su{PAR}, s{EPCR}, s{ICAM}-1, s{T}ie-2 and {A}ng-2 were higher among children who died from severe malaria compared to those who survived (p = 0.037, p = 0.035, p < 0.0001, p= 0.0008, p = 0.01 and p = 0.02, respectively). {T}hese findings indicate the ability of these molecules to accurately discriminate among clinical manifestations of malaria, thus, they might be potentially useful for the early prognostic of severe and fatal malaria, and to improve management of severe cases.},
  keywords = {cerebral malaria ; biomarkers ; s{ICAM}-1 ; {EPCR} ; {PTX}3 ; {PCT} ; su{PAR} ; s{T}ie-2 ; {A}ng-2 ; {BENIN}},
  booktitle = {},
  journal = {{D}iagnostics},
  volume = {12},
  numero = {2},
  pages = {524 [17 p.]},
  year = {2022},
  DOI = {10.3390/diagnostics12020524},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084350},
}