%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Garrison, A.
%A Boivin, M. J.
%A Fievet, Nadine
%A Zoumenou, R.
%A Alao, J. M.
%A Massougbodji, A.
%A Cot, Michel
%A Bodeau-Livinec, F.
%T The effects of malaria in pregnancy on neurocognitive development in children at 1 and 6 years of age in Benin : a prospective mother-child cohort
%D 2022
%L fdi:010084293
%G ENG
%J Clinical Infectious Diseases
%@ 1058-4838
%K child development ; malaria ; neurocognition ; pregnancy ; sub-Saharan ; Africa
%K BENIN ; AFRIQUE SUBSAHARIENNE
%M ISI:000756415100001
%N 5
%P 766-775
%R 10.1093/cid/ciab569
%U https://www.documentation.ird.fr/hor/fdi:010084293
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2022-04/010084293.pdf
%V 74
%W Horizon (IRD)
%X Background Malaria in pregnancy (MiP) contributes significantly to infant mortality rates in sub-Saharan Africa and has consequences on survivors, such as preterm birth and low birth weight. However, its impact on long-term neurocognitive development in children remains unknown. Methods Our prospective cohort included pregnant women and their live-born singletons from the Malaria in Pregnancy Preventive Alternative Drugs clinical trial. MiP was assessed using microscopy and real-time quantitative polymerase chain reaction (qPCR). Neurocognitive development in children was assessed using the Mullen Scales of Early Learning and the Kaufman Assessment Battery for Children, 2nd edition (KABC-II), at 1 and 6 years of age, respectively. Results Of 493 pregnant women, 196 (40%) were infected with malaria at least once: 121 (31%) with placental malaria diagnosed by qPCR. Multiple linear regression B-coefficients showed that impaired gross motor scores were associated with MiP at least once (-2.55; confidence interval [95% CI]: -5.15, 0.05), placental malaria by qPCR (-4.95; 95% CI: -7.65, -2.24), and high parasite density at delivery (-1.92; 95% CI: -3.86, 0.02) after adjustment. Malaria and high parasite density at the second antenatal care visit were associated with lower KABC-II Non-Verbal Index scores at 6 years (-2.57 [95% CI: -4.86, -0.28] and -1.91 [-3.51, -0.32]), respectively. Conclusions This prospective cohort study provides evidence that MiP, particularly late term, could have important negative consequences on child development at 1 and 6 years of age. Mechanisms behind this association must be further investigated and diagnostic methods in low-income countries should be strengthened to provide adequate treatment. This paper provides the first evidence of an association between late-term peripheral and placental malaria in pregnancy and impaired neurocognitive development in offspring at 1 and 6 years of age in Benin, sub-Saharan Africa.
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