@article{fdi:010084293,
  title = {{T}he effects of malaria in pregnancy on neurocognitive development in children at 1 and 6 years of age in {B}enin : a prospective mother-child cohort},
  author = {{G}arrison, {A}. and {B}oivin, {M}. {J}. and {F}ievet, {N}adine and {Z}oumenou, {R}. and {A}lao, {J}. {M}. and {M}assougbodji, {A}. and {C}ot, {M}ichel and {B}odeau-{L}ivinec, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {M}alaria in pregnancy ({M}i{P}) contributes significantly to infant mortality rates in sub-{S}aharan {A}frica and has consequences on survivors, such as preterm birth and low birth weight. {H}owever, its impact on long-term neurocognitive development in children remains unknown. {M}ethods {O}ur prospective cohort included pregnant women and their live-born singletons from the {M}alaria in {P}regnancy {P}reventive {A}lternative {D}rugs clinical trial. {M}i{P} was assessed using microscopy and real-time quantitative polymerase chain reaction (q{PCR}). {N}eurocognitive development in children was assessed using the {M}ullen {S}cales of {E}arly {L}earning and the {K}aufman {A}ssessment {B}attery for {C}hildren, 2nd edition ({KABC}-{II}), at 1 and 6 years of age, respectively. {R}esults {O}f 493 pregnant women, 196 (40%) were infected with malaria at least once: 121 (31%) with placental malaria diagnosed by q{PCR}. {M}ultiple linear regression {B}-coefficients showed that impaired gross motor scores were associated with {M}i{P} at least once (-2.55; confidence interval [95% {CI}]: -5.15, 0.05), placental malaria by q{PCR} (-4.95; 95% {CI}: -7.65, -2.24), and high parasite density at delivery (-1.92; 95% {CI}: -3.86, 0.02) after adjustment. {M}alaria and high parasite density at the second antenatal care visit were associated with lower {KABC}-{II} {N}on-{V}erbal {I}ndex scores at 6 years (-2.57 [95% {CI}: -4.86, -0.28] and -1.91 [-3.51, -0.32]), respectively. {C}onclusions {T}his prospective cohort study provides evidence that {M}i{P}, particularly late term, could have important negative consequences on child development at 1 and 6 years of age. {M}echanisms behind this association must be further investigated and diagnostic methods in low-income countries should be strengthened to provide adequate treatment. {T}his paper provides the first evidence of an association between late-term peripheral and placental malaria in pregnancy and impaired neurocognitive development in offspring at 1 and 6 years of age in {B}enin, sub-{S}aharan {A}frica.},
  keywords = {child development ; malaria ; neurocognition ; pregnancy ; sub-{S}aharan ; {A}frica ; {BENIN} ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{C}linical {I}nfectious {D}iseases},
  volume = {74},
  numero = {5},
  pages = {766--775},
  ISSN = {1058-4838},
  year = {2022},
  DOI = {10.1093/cid/ciab569},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084293},
}