@article{fdi:010084279,
  title = {{H}igh levels of pathological jaundice in the first 24 hours and neonatal hyperbilirubinaemia in an epidemiological cohort study on the {T}hailand-{M}yanmar border},
  author = {{T}hielemans, {L}. and {P}eerawaranun, {P}. and {M}ukaka, {M}. and {P}aw, {M}. {K}. and {W}iladphaingern, {J}. and {L}andier, {J}ordi and {B}ancone, {G}. and {P}roux, {S}. and {E}lsinga, {H}. and {T}rip-{H}oving, {M}. and {H}anboonkunupakarn, {B}. and {H}too, {T}. {L}. and {W}ah, {T}. {S}. and {B}eau, {C}. and {N}osten, {F}. and {M}c{G}ready, {R}. and {C}arrara, {V}. {I}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}opulation risks for neonatal hyperbilirubinaemia ({NH}) vary. {K}nowledge of local risks permits interventions that may reduce the proportion becoming severe. {B}etween {J}anuary 2015 and {M}ay 2016, in a resource-limited setting on the {T}hailand-{M}yanmar border, neonates from 28 weeks' gestation were enrolled into a prospective birth cohort. {E}ach neonate had total serum bilirubin measurements: scheduled (24, 48, 72 and 144 hours of life) and clinically indicated; and weekly follow up until 1 month of age. {R}isk factors for developing {NH} were evaluated using {C}ox proportional hazard mixed model. {O}f 1710 neonates, 22% (376) developed {NH} (83% preterm, 19% term). {A}ll neonates born <35 weeks, four in five born 35-37 weeks, and three in twenty born >= 38 weeks had {NH}, giving an overall incidence of 249 per 1000 livebirths [95%{CI} 225, 403]. {M}ortality from acute bilirubin encephalopathy was 10% (2/20) amongst the 5.3% (20/376) who reached the severe {NH} threshold. {O}ne-quarter (26.3%) of {NH} occurred within 24 hours. {NH} onset varied with gestational age: at a median [{IQR}] 24 hours [24, 30] for neonates born 37 weeks or prematurely vs 59 hours [48, 84] for neonates born >= 38 weeks. {R}isk factors for {NH} in the first week of life independent of gestational age were: neonatal {G}6{PD} deficiency, birth bruising, {S}gaw {K}aren ethnicity, primigravidae, pre-eclampsia, and prolonged rupture of membranes. {T}he genetic impact of {G}6{PD} deficiency on {NH} was partially interpreted by using the florescent spot test and further genotyping work is in progress. {T}he risk of {NH} in {S}gaw {K}aren refugees may be overlooked internationally as they are most likely regarded as {B}urmese in countries of resettlement. {G}iven high levels of pathological jaundice in the first 24 hours and overall high {NH} burden, guidelines changes were implemented including preventive {PT} for all neonates <35 weeks and for those 35-37 weeks with risk factors.},
  keywords = {{THAILANDE} ; {MYANMAR}},
  booktitle = {},
  journal = {{PL}o{S} {O}ne},
  volume = {16},
  numero = {10},
  pages = {e0258127 [17 p.]},
  ISSN = {1932-6203},
  year = {2021},
  DOI = {10.1371/journal.pone.0258127},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084279},
}