@article{fdi:010084278,
  title = {{N}asopharyngeal pneumococcal colonization density is associated with severe pneumonia in young children in the {L}ao poeple's {D}emocratic {R}epublic},
  author = {{C}arr, {O}. {J}. {J}. and {V}ilivong, {K}. and {B}ounvilay, {L}. and {D}unne, {E}. {M}. and {L}ai, {J}. {Y}. {R}. and {C}han, {J}. and {V}ongsakid, {M}. and {C}hangthongthip, {A}. and {S}iladeth, {C}. and {O}rtika, {B}. and {N}guyen, {C}. and {M}ayxay, {M}. and {N}ewton, {P}. {N}. and {M}ulholland, {K}. and {D}o, {L}. {A}. {H}. and {D}ubot {P}{\'e}r{\`e}s, {A}udrey and {S}atzke, {C}. and {D}ance, {D}. {A}. {B}. and {R}ussell, {F}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{N}o studies have explored the association between pneumococcal nasopharyngeal density and severe pneumonia using the {W}orld {H}ealth {O}rganization 2013 definition. {A}mong children with acute respiratory infections and pneumococcal carriage, pneumococcal carriage density was positively associated with severe pneumonia in {L}aos. {B}ackground {N}o studies have explored the association between pneumococcal nasopharyngeal density and severe pneumonia using the {W}orld {H}ealth {O}rganization ({WHO}) 2013 definition. {I}n {L}ao {P}eople's {D}emocratic {R}epublic ({L}ao {PDR}), we determine the association between nasopharyngeal pneumococcal density and severe pneumonia in children. {M}ethods {A} prospective observational study was undertaken at {M}ahosot {H}ospital, {V}ientiane, from 2014 to mid-2018. {C}hildren <5 years admitted with acute respiratory infections ({ARI}s) were included. {C}linical and demographic data were collected alongside nasopharyngeal swabs for pneumococcal quantification by lyt{A} real-time quantitative polymerase chain reaction. {S}evere pneumonia was defined using the 2013 {WHO} definition. {F}or pneumococcal carriers, a logistic regression model examined the association between pneumococcal density and severe pneumonia, after adjusting for potential confounders including demographic and household factors, 13-valent pneumococcal conjugate vaccine status, respiratory syncytial virus co-detection, and preadmission antibiotics. {R}esults {O}f 1268 participants with {ARI}, 32.3% (n = 410) had severe pneumonia and 36.9% (n = 468) had pneumococcal carriage. {F}or pneumococcal carriers, pneumococcal density was positively associated with severe pneumonia (adjusted odds ratio, 1.4 [95% confidence interval, 1.1-1.8]; {P} = .020). {C}onclusions {A}mong children with {ARI}s and pneumococcal carriage, pneumococcal carriage density was positively associated with severe pneumonia in {L}ao {PDR}. {F}urther studies may determine if pneumococcal density is a useful marker for pneumococcal conjugate vaccine impact on childhood pneumonia.},
  keywords = {pneumococcus ; pneumonia ; density ; nasopharynx ; {LAOS}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[8 p.]},
  ISSN = {0022-1899},
  year = {2022},
  DOI = {10.1093/infdis/jiab239},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084278},
}