@article{fdi:010084277,
  title = {{F}irst evaluation of antibody responses to {C}ulex quinquefasciatus salivary antigens as a serological biomarker of human exposure to {C}ulex bites : a pilot study in {C}ote d'lvoire},
  author = {{Z}amble, {B}. {Z}. {H}. and {Y}ao, {S}. {S}. and {A}dja, {A}. {M}. and {B}akli, {M}. and {Z}oh, {D}. {D}. and {M}athieu-{D}aud{\'e}, {F}ran{\c{c}}oise and {A}ssi, {S}. {B}. and {R}emou{\'e}, {F}ranck and {A}lmeras, {L}. and {P}oinsignon, {A}nne},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {C}ulex mosquitoes are vectors for a variety of pathogens of public health concern. {N}ew indicators of exposure to {C}ulex bites are needed to evaluate the risk of transmission of associated pathogens and to assess the efficacy of vector control strategies. {A}n alternative to entomological indices is the serological measure of antibodies specific to mosquito salivary antigens. {T}his study investigated whether the human {I}g{G} response to both the salivary gland extract and the 30 k{D}a salivary protein of {C}ulex quinquefasciatus may represent a proxy of human exposure to {C}ulexbites. {M}ethodology/{P}rincipal findings {A} multidisciplinary survey was conducted with children aged 1 to 14 years living in neighborhoods with varying exposure to {C}ulex quinquefasciatus in the city of {B}ouake, {C}ote d'lvoire. {C}hildren living in sites with high exposure to {C}x quinquefasciatus had a significantly higher {I}g{G} response to both salivary antigens compared with children living in the control site where only very few {C}ulex were recorded. {M}oreover, children from any {C}ulex-high exposed sites had significantly higher {I}g{G} responses only to the salivary gland extract compared with children from the control village, whereas no difference was noted in the anti-30 k{D}a {I}g{G} response. {N}o significant differences were noted in the specific {I}g{G} responses between age and gender. {S}ites and the use of a bed net were associated with the level of {I}g{G} response to the salivary gland extract and to the 30 k{D}a antigen, respectively. {C}onclusions/{S}ignificance {T}hese findings suggest that the {I}g{G} response to {C}u/exsalivary gland extracts is suitable as proxy of exposure; however, the specificity to the {C}ulex genus needs further investigation. {T}he lower antigenicity of the 30 k{D}a recombinant protein represents a limitation to its use. {T}he high specificity of this protein to the {C}ulex genus makes it an attractive candidate and other specific antibody responses might be more relevant as a biomarker of exposure. {T}hese epidemiological observations may form a starting point for additional work on developing serological biomarkers of {C}ulex exposure.},
  keywords = {{COTE} {D}'{IVOIRE}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {15},
  numero = {12},
  pages = {e0010004 [20 ]},
  ISSN = {1935-2735},
  year = {2021},
  DOI = {10.1371/journal.pntd.0010004},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084277},
}