@article{fdi:010084244,
  title = {{SARS}-{C}o{V}-2 vaccination and protection against clinical disease : a retrospective study, {B}ouches-du-{R}hone {D}istrict, {S}outhern {F}rance, 2021},
  author = {{F}ournier, {P}. {E}. and {H}ouhamdi, {L}. and {C}olson, {P}. and {C}ortaredona, {S}{\'e}bastien and {D}elorme, {L}. and {C}assagne, {C}. and {L}agier, {J}. {C}. and {C}haudet, {H}. and {T}issot-{D}upont, {H}. and {G}iraud-{G}atineau, {A}. and {F}enollar, {F}. and {M}illion, {M}. and {R}aoult, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{F}rom {J}anuary 18th to {A}ugust 13th, 2021, 13,804 unvaccinated and 1,156 patients who had received at least one {COVID}-19 vaccine dose were tested q{PCR}-positive for {SARS}-{C}o{V}-2 in our center. {A}mong vaccinated patients, 949, 205 and 2 had received a single, two or three vaccine doses, respectively. {M}ost patients (80.3%) had received the {P}fizer-{B}io{NT}ech vaccine. {T}he {SARS}-{C}o{V}-2 variants infecting vaccinated patients varied over time, reflecting those circulating in the {M}arseille area, with a predominance of the {M}arseille-4/20{A}.{EU}2 variant from weeks 3 to 6, of the {A}lpha/20{I} variant from weeks 7 to 25, and of the {D}elta/21{A} variant from week 26. {SARS}-{C}o{V}-2 infection was significantly more likely to occur in the first 13 days post-vaccine injection in those who received a single dose (48.9%) than two doses (27.4%, p< 10(-3)). {A}mong 161 patients considered as fully vaccinated, i.e., >14 days after the completion of the vaccinal scheme (one dose for {J}ohnson and {J}ohnson and two doses for {P}fizer/{B}io{NT}ech, {M}oderna and {S}putnik vaccines), 10 (6.2%) required hospitalization and four (2.5%) died. {R}isks of complications increased with age in a nonlinear pattern, with a first breakpoint at 54, 33, and 53 years for death, transfer to {ICU}, and hospitalization, respectively. {A}mong patients infected by the {D}elta/21{A} or {A}lpha/20{I} variants, partial or complete vaccination exhibited a protective effect with a risk divided by 3.1 for mortality in patients >= 55 years, by 2.8 for {ICU} transfer in patients >= 34 years, and by 1.8 for hospitalization in patients >= 54 years. {C}ompared to partial vaccination, complete vaccination provided an even stronger protective effect, confirming effectiveness to prevent severe forms of {COVID}-19.},
  keywords = {{COVID}-19 ; {SARS}-{C}o{V}-2 ; vaccine ; death ; intensive care ; hospitalization ; protective effect ; {FRANCE} ; {BOUCHES} {DU} {RHONE}},
  booktitle = {},
  journal = {{F}rontiers in {M}icrobiology},
  volume = {12},
  numero = {},
  pages = {796807 [10 ]},
  year = {2022},
  DOI = {10.3389/fmicb.2021.796807},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084244},
}