@article{fdi:010084237,
  title = {{P}f{EMP}1-specific immunoglobulin {G} reactivity among {B}eninese pregnant women with sickle cell trait},
  author = {{L}opez-{P}erez, {M}. and {V}iwami, {F}. and {S}eidu, {Z}. and {J}ensen, {A}. {T}. {R}. and {D}oritchamou, {J}. and {T}uikue {N}dam, {N}icaise and {H}viid, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {S}ickle cell trait ({H}b{AS}) protects against severe {P}lasmodium falciparum malaria but not against placental malaria ({PM}). {I}n this study, {P} falciparum erythrocyte membrane protein ({P}f{EMP}1)-specific antibodies were measured in {H}b{AA} and {H}b{AS} {B}eninese pregnant women as a proxy of exposure to specific {P}f{EMP}1 variants. {M}ethods. {P}lasma samples collected at delivery from 338 {H}b{AA} and 63 {H}b{AS} women were used to measure immunoglobulin ({I}g){G} levels to 6 recombinant {P}f{EMP}1 proteins and 3 corresponding native proteins expressed on the infected erythrocyte ({IE}) surface. {I}mmunoglobulin {G}-mediated inhibition of {VAR}2{CSA}(+) {IE}s adhesion to chondroitin sulfate {A} ({CSA}) was also tested. {R}esults. {L}evels of {P}f{EMP}1-specific {I}g{G} were similar in the 2 groups, except for native {IT}4{VAR}09 on {IE}s, where {I}g{G} levels were significantly higher in {H}b{AS} women. {A}djusted odds ratios for women with positive {I}g{G} to {HB}3{VAR}06 and {PFD}1235w suggest a lower risk of infection with these virulent variants among {H}b{AS} individuals. '{I}he percentage of {IE}s binding to {CSA} did not differ between {H}b{AA} and {H}b{AS} women, but it correlated positively with levels of anti-{VAR}2{CSA} and parity. {W}omen with {PM} had lower levels of anti-{VAR}2{CSA}-specific {I}g{G} and lower {I}g{G}-mediated inhibition of {IE} adhesion to {CSA}. {C}onclusions. {T}he findings support similar malaria exposure in {H}b{AA} and {H}b{AS} women and a lack of {H}b{AS}-dependent protection against placental infection among pregnant women.},
  keywords = {{B}enin ; {P}f{EMP}1 ; placental malaria ; {P}lasmodium falciparum ; sickle cell trait ; {BENIN}},
  booktitle = {},
  journal = {{O}pen {F}orum {I}nfectious {D}iseases},
  volume = {8},
  numero = {12},
  pages = {ofab527 [9 ]},
  ISSN = {2328-8957},
  year = {2021},
  DOI = {10.1093/ofid/ofab527},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084237},
}