@article{fdi:010083967,
  title = {{C}haracterization of the gut microbiota in individuals with overweight or obesity during a real-world weight loss dietary program : a focus on the bacteroides 2 enterotype},
  author = {{A}lili, {R}. and {B}elda, {E}. and {F}abre, {O}. and {P}elloux, {V}. and {G}iordano, {N}. and {L}egrand, {R}. and {L}assen, {P}. {B}. and {S}wartz, {T}. {D}. and {Z}ucker, {J}ean-{D}aniel and {C}lement, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {D}ietary intervention is a cornerstone of weight loss therapies. {I}n obesity, a dysbiotic gut microbiota ({GM}) is characterized by high levels of {B}acteroides lineages and low diversity. {W}e examined the {GM} composition changes, including the {B}acteroides 2 enterotype ({B}act2), in a real-world weight loss study in subjects following a high-protein hypocaloric diet with or without a live microorganisms ({LMP}) supplement. {M}ethod: 263 volunteers were part of this real-world weight loss program. {T}he first phase was a high-protein low-carbohydrate calorie restriction diet with or without {LMP} supplements. {F}ecal samples were obtained at baseline and after 10% weight loss for 163 subjects. {M}etagenomic profiling was obtained by shotgun sequencing. {R}esults: {A}t baseline, the {B}act2 enterotype was more prevalent in subjects with aggravated obesity and metabolic alterations. {A}fter weight loss, diversity increased and {B}act2 prevalence decreased in subjects with lower {GM} diversity at baseline, notably in {LMP} consumers. {S}ignificant increases in {A}kkermansia muciniphila and {P}arabacteroides distasonis and significant decreases of {E}ubacterium rectale, {S}treptococcus thermophilus and {B}ifidobacterial lineages were observed after weight loss. {C}onclusions: {B}aseline microbiome composition is associated with differential changes in {GM} diversity and {B}act2 enterotype prevalence after weight loss. {E}xamining these signatures could drive future personalized nutrition efforts towards more favorable microbiome compositions.},
  keywords = {obesity ; gut microbiota ; weight loss ; {B}acteroides 2 enterotype ; real-world dietary intervention ; nanopore technology ; {FRANCE}},
  booktitle = {},
  journal = {{B}iomedicines},
  volume = {10},
  numero = {1},
  pages = {16 [23 p.]},
  year = {2022},
  DOI = {10.3390/biomedicines10010016},
  URL = {https://www.documentation.ird.fr/hor/fdi:010083967},
}