@article{fdi:010083908, title = {{N}iclosamide shows strong antiviral activity in a human airway model of {SARS}-{C}o{V}-2 infection and a conserved potency against the {A}lpha ({B}.1.1.7), {B}eta ({B}.1.351) and {D}elta variant ({B}.1.617.2)}, author = {{W}eiss, {A}. and {T}ouret, {F}. and {B}aronti, {C}{\'e}cile and {G}illes, {M}agali and {H}oen, {B}. and {N}ougairede, {A}. and {L}amballerie, {X}. de and {S}ommer, {M}. {O}. {A}.}, editor = {}, language = {{ENG}}, abstract = {{SARS}-{C}o{V}-2 variants are emerging with potential increased transmissibility highlighting the great unmet medical need for new therapies. {N}iclosamide is a potent anti-{SARS}-{C}o{V}-2 agent that has advanced in clinical development. {W}e validate the potent antiviral efficacy of niclosamide in a {SARS}-{C}o{V}-2 human airway model. {F}urthermore, niclosamide remains its potency against the {D}614{G}, {A}lpha ({B}.1.1.7), {B}eta ({B}.1.351), and {D}elta ({B}.1.617.2) variants. {O}ur data further support the potent anti-{SARS}-{C}o{V}-2 properties of niclosamide and highlights its great potential as a therapeutic agent for {COVID}-19.}, keywords = {}, booktitle = {}, journal = {{PL}o{S} {O}ne}, volume = {16}, numero = {12}, pages = {e0260958 [8 ]}, ISSN = {1932-6203}, year = {2021}, DOI = {10.1371/journal.pone.0260958}, URL = {https://www.documentation.ird.fr/hor/fdi:010083908}, }