@article{fdi:010083905,
  title = {{A}ssociations between zinc and hemoglobin concentrations in preschool children and women of reproductive age : an analysis of representative survey data from the {B}iomarkers {R}eflecting {I}nflammation {A}nd {N}utritional {D}eterminants {O}f {A}nemia ({BRINDA}) project},
  author = {{G}reffeuille, {V}al{\'e}rie and {F}ortin, {S}onia and {G}ibson, {R}. and {R}ohner, {F}. and {W}illiams, {A}. and {Y}oung, {M}. {F}. and {H}oughton, {L}. and {O}u, {J}. {D}. and {D}ijkhuizen, {M}. {A}. and {W}irth, {J}. {P}. and {L}ander, {R}. {L}. and {M}c{D}onald, {C}. {M}. and {S}uchdev, {P}. {S}. and {B}erger, {J}acques and {W}ieringa, {F}ranck},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}nemia is a worldwide concern. {N}utritional deficiencies and inflammation are considered main contributors, but zinc deficiency has only recently been associated with anemia. {O}bjectives: {I}n this study we assessed associations between zinc status and hemoglobin ({H}b) concentrations and anemia in preschool children 6-59 mo old ({PSC}) and nonpregnant women of reproductive age 15-49 y old ({WRA}) in population-based nutrition surveys. {M}ethods: {C}ross-sectional data from 13 ({PSC}) and 12 ({IRA}) countries within the {B}iomarkers {R}eflecting {I}nflammation and {N}utritional {D}eterminants of {A}nemia ({BRINDA}) project were used. {M}ultivariable linear models were constructed that included zinc status (plasma/serum zinc concentrations), {H}b concentrations and anemia, iron status, age, sex, and inflammation ({C}-reactive protein and alpha-1-acid glycoprotein). {Z}inc was adjusted for inflammation in {PSC} according to the {BRINDA} algorithm. {R}esults: {D}ata were available for 18,658 {PSC} and 22,633 {WRA}. {P}revalence of anemia ranged from 75% to 73.7% and from 11.5% to 94.7% in {PSC} and {WRA}, respectively. {P}revalence of zinc deficiency ranged from 9.2% to 78.4% in {PSC} and from 9.8% to 84.7% in {WRA}, with prevalence of zinc deficiency >20% in all countries except {A}zerbaijan ({PSC}), {E}cuador ({PSC}), and the {U}nited {K}ingdom ({WRA}). {M}ultivariable linear regression models showed that zinc concentrations were independently and positively associated with {H}b concentrations in 7 of 13 countries for {PSC} and 5 of 12 countries for {WRA}. {I}n the same models, ferritin concentration was also significantly associated with {H}b among {PSC} and {WRA} in 9 and 10 countries, respectively. {Z}inc deficiency was significantly associated with anemia in {PSC} and {WRA} in 5 and 4 countries respectively. {C}onclusions: {Z}inc deficiency was prevalent in most countries and associations between zinc and {H}b in roughly half of the countries examined suggesting that strategies to combat zinc deficiency may help reduce anemia prevalence. {M}ore research on mechanisms by which zinc deficiency is associated with anemia and the reasons for the heterogeneity among countries is warranted.},
  keywords = {anemia ; zinc deficiency ; inflammation ; preschool children ; women of reproductive age ; {AFGHANISTAN} ; {AZERBAIDJAN} ; {BANGLADESH} ; {BURKINA} {FASO} ; {CAMBODGE} ; {CAMEROUN} ; {COLOMBIE} ; {EQUATEUR} ; {INDE} ; {MALAWI} ; {MEXIQUE} ; {MONGOLIE} ; {PAKISTAN} ; {ROYAUME} {UNI} ; {VIET} {NAM}},
  booktitle = {},
  journal = {{J}ournal of {N}utrition},
  volume = {151},
  numero = {5},
  pages = {1277--1285},
  ISSN = {0022-3166},
  year = {2021},
  DOI = {10.1093/jn/nxaa444},
  URL = {https://www.documentation.ird.fr/hor/fdi:010083905},
}