@article{fdi:010083839,
  title = {{F}lying fox hemolytic fever, description of a new zoonosis caused by candidatus {M}ycoplasma haemohominis},
  author = {{D}escloux, {E}. and {M}ediannikov, {O}leg and {G}ourinat, {A}. {C}. and {C}olot, {J}. and {C}hauvet, {M}. and {M}ermoud, {I}. and {D}esoutter, {D}. and {C}azorla, {C}. and {K}lement-{F}rutos, {E}. and {A}ntonini, {L}. and {L}evasseur, {A}. and {B}ossi, {V}. and {D}avoust, {B}. and {M}erlet, {A}. and {G}oujart, {M}. {A}. and {O}edin, {M}. and {B}rescia, {F}. and {L}aumond, {S}. and {F}ournier, {P}. {E}. and {R}aoult, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {H}emotropic mycoplasmas, previously classified in the genus {E}perythrozoon, have been reported as causing human infections in {B}razil, {C}hina, {J}apan, and {S}pain. {M}ethods. {I}n 2017, we detected {DNA} from {C}andidatus {M}ycoplasma haemohominis in the blood of a {M}elanesian patient from {N}ew {C}aledonia presenting with febrile splenomegaly, weight loss, life-threatening autoimmune hemolytic anemia, and hemophagocytosis. {T}he full genome of the bacterium was sequenced from a blood isolate. {S}ubsequently, we retrospectively (20112017) and prospectively (2018-2019) tested patients who had been hospitalized with a similar clinico-biological picture. {I}n addition, as these patients had been in contact with frugivorous bats (authorized under conditions for hunting and eating in {N}ew {C}aledonia), we investigated the role of these animals and their biting flies by testing them for hemotropic mycoplasmas. {R}esults. {T}here were 15 patients found to be infected by this hemotropic mycoplasma. {A}mong them, 4 (27%) died following splenectomy performed either for spontaneous spleen rupture or to cure refractory autoimmune hemolytic anemia. {T}he bacterium was cultivated from the patient's blood. {T}he full genome of the {N}eocaledonian {C}andidatus {M}. haemohominis strain differed from that of a recently identified {J}apanese strain. {O}f 40 tested {P}teropus bats, 40% were positive; 100% of collected bat flies {C}yclopodia horsfieldi ({N}ycteribiidae, {D}iptera) were positive. {H}uman, bat, and dipteran strains were highly similar. {C}onclusions. {T}he bacterium being widely distributed in bats, {C}andidatus {M}. haemohominis, should be regarded as a potential cause of severe infections in humans.},
  keywords = {{C}andidatus {M}ycoplasma haemohominis ; {N}ew {C}aledonia ; bats ; autoimmune ; hemolytic anemia ; hemophagocytosis ; {NOUVELLE} {CALEDONIE}},
  booktitle = {},
  journal = {{C}linical {I}nfectious {D}iseases},
  volume = {73},
  numero = {7},
  pages = {{E}1445--{E}1453},
  ISSN = {1058-4838},
  year = {2021},
  DOI = {10.1093/cid/ciaa1648},
  URL = {https://www.documentation.ird.fr/hor/fdi:010083839},
}