@article{fdi:010083804,
  title = {{L}ipid {I}nteractions between flaviviruses and mosquito vectors},
  author = {{V}ial, {T}homas and {M}arti, {G}. and {M}iss{\'e}, {D}oroth{\'e}e and {P}ompon, {J}ulien},
  editor = {},
  language = {{ENG}},
  abstract = {{M}osquito-borne flaviviruses, such as dengue ({DENV}), {Z}ika ({ZIKV}), yellow fever ({YFV}), {W}est {N}ile ({WNV}), and {J}apanese encephalitis ({JEV}) viruses, threaten a large part of the human populations. {I}n absence of therapeutics and effective vaccines against each flaviviruses, targeting viral metabolic requirements in mosquitoes may hold the key to new intervention strategies. {D}evelopment of metabolomics in the last decade opened a new field of research: mosquito metabolomics. {I}t is now clear that flaviviruses rely on mosquito lipids, especially phospholipids, for their cellular cycle and propagation. {H}ere, we review the biosyntheses of, biochemical properties of and flaviviral interactions with mosquito phospholipids. {P}hospholipids are structural lipids with a polar headgroup and apolar acyl chains, enabling the formation of lipid bilayer that form plasma- and endomembranes. {P}hospholipids are mostly synthesized through the de novo pathway and remodeling cycle. {V}ariations in headgroup and acyl chains influence phospholipid physicochemical properties and consequently the membrane behavior. {F}laviviruses interact with cellular membranes at every step of their cellular cycle. {R}ecent evidence demonstrates that flaviviruses reconfigure the phospholipidome in mosquitoes by regulating phospholipid syntheses to increase virus multiplication. {I}dentifying the phospholipids involved and understanding how flaviviruses regulate these in mosquitoes is required to design new interventions.},
  keywords = {mosquito ; flavivirus ; phospholipids ; transmission ; metabolomics},
  booktitle = {},
  journal = {{F}rontiers in {P}hysiology},
  volume = {12},
  numero = {},
  pages = {763195 [19 ]},
  ISSN = {1664-042{X}},
  year = {2021},
  DOI = {10.3389/fphys.2021.763195},
  URL = {https://www.documentation.ird.fr/hor/fdi:010083804},
}