%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Bengue, Michèle
%A Pintong, A.
%A Liégeois, Florian
%A Nougairede, A.
%A Hamel, Rodolphe
%A Pompon, Julien
%A Lamballerie, X. de
%A Roques, P.
%A Choumet, V.
%A Missé, Dorothée
%T Favipiravir inhibits Mayaro virus infection in mice
%D 2021
%L fdi:010083796
%G ENG
%J Viruses
%K alphavirus ; arbovirus ; mayaro ; favipiravir ; antiviral drug
%M ISI:000726022400001
%N 11
%P 2213 [17 ]
%R 10.3390/v13112213
%U https://www.documentation.ird.fr/hor/fdi:010083796
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2022-01/010083796.pdf
%V 13
%W Horizon (IRD)
%X Mayaro virus (MAYV) is an emergent alphavirus that causes MAYV fever. It is often associated with debilitating symptoms, particularly arthralgia and myalgia. MAYV infection is becoming a considerable health issue that, unfortunately, lacks a specific antiviral treatment. Favipiravir, a broad-spectrum antiviral drug, has recently been shown to exert anti-MAYV activity in vitro. In the present study, the potential of Favipiravir to inhibit MAYV replication in an in vivo model was evaluated. Immunocompetent mice were orally administrated 300 mg/kg/dose of Favipiravir at pre-, concurrent-, or post-MAYV infection. The results showed a significant reduction in infectious viral particles and viral RNA transcripts in the tissues and blood of the pre- and concurrently treated infected mice. A significant reduction in the presence of both viral RNA transcript and infectious viral particles in the tissue and blood of pre- and concurrently treated infected mice was observed. By contrast, Favipiravir treatment post-MAYV infection did not result in a reduction in viral replication. Interestingly, Favipiravir strongly decreased the blood levels of the liver disease markers aspartate- and alanine aminotransferase in the pre- and concurrently treated MAYV-infected mice. Taken together, these results suggest that Favipiravir is a potent antiviral drug when administered in a timely manner.
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