Holzmuller P. auteur aut IRD Grébaut Pascal auteur aut IRD Cuny Gérard auteur aut IRD Biron D. G. auteur aut IRD text journalArticle eng text/pdf born digital access Human and animal African trypanosomoses, or sleeping sickness and Nagana, are neglected vector-borne parasitic diseases caused by protozoa belonging to the Trypanosoma genus. Advances in proteomics offer new tools to better understand host-vector-parasite crosstalks occurring during the complex parasitic developmental cycle, and to determine the outcome of both transmission and infection. In this review, we summarize proteomics studies performed on African trypanosomes and on the interactions with their vector and mammalian hosts. We discuss the contributions and pitfalls of using diverse proteomics tools, and argue about the interest of pathogenoproteomics, both to generate advances in basic research on the best knowledge and understanding of host-vector-pathogen interactions, and to lead to the concrete development of new tools to improve diagnosis and treatment management of trypanosomoses in the near future. specialized African trypanosome host-vector-parasite interaction proteomics 052 7 1 113-126 2010 1478-9450 https://www.documentation.ird.fr/hor/fdi:010083646 10.1586/epr.09.92 1478-9450 [F B010083646] https://www.documentation.ird.fr/hor/fdi:010083646 https://www.documentation.ird.fr/intranet/publi/2021-11/010083646.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2010-04-06 2021-11-29 fdi:010083646 fre