N'Do S., Bandibabone J. B., Soma D. D., Musaka B. Z., Prudhomme J., Habamungu C. C., Namountougou M., Sangare I., Kientega M., Kabore D. A. P., Bayili K., Yerbanga R. S., Diabate A., Dabire R. K., Ouedraogo J. B., Belem A. M. G., Boëte Christophe, Guardiola-Claramonte M., Chimanuka B. (2021). Insecticide resistance profiles in malaria vector populations from Sud-Kivu in the Democratic Republic of the Congo. Transactions of the Royal Society of Tropical Medicine and Hygiene, 115 (11), p. 1339-1344. ISSN 0035-9203.
Titre du document
Insecticide resistance profiles in malaria vector populations from Sud-Kivu in the Democratic Republic of the Congo
Année de publication
2021
Auteurs
N'Do S., Bandibabone J. B., Soma D. D., Musaka B. Z., Prudhomme J., Habamungu C. C., Namountougou M., Sangare I., Kientega M., Kabore D. A. P., Bayili K., Yerbanga R. S., Diabate A., Dabire R. K., Ouedraogo J. B., Belem A. M. G., Boëte Christophe, Guardiola-Claramonte M., Chimanuka B.
Source
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2021,
115 (11), p. 1339-1344 ISSN 0035-9203
Background: Insecticide resistance has become a widespread problem causing a decline in the effectiveness of vector control took in sub-Saharan Africa. In this situation, ongoing monitoring of vector susceptibility to insecticides is encouraged by the WHO to guide national malaria control programmes. Our study was conducted from April to November 2018 in Tchonka (Sud-Kivu, Democratic Republic of the Congo) and reported primary data on the resistance status of Anopheles funestus and Anopheles gambiae. Methods: Insecticide susceptibility bioassays were performed on wild populations of A. funestus and A. gambiae using WHO insecticide-impregnated papers at discriminating concentration. In addition, PCR was performed to identify mosquito species and to detect kdr and ace-1(R) mutations involved in insecticide resistance. Results: Bioassay results show resistance to all tested insecticides except pirimiphos-methyl, propoxur, fenitrothion and malathion with a mortality rate ranging from 95.48 to 99.86%. The addition of piperonyl butoxide (PBO) increased the susceptibility of vectors to deltamethrin and alpha-cypermethrin by exhibiting a mortality ranging from 91.50 to 95.86%. The kdr mutation was detected at high frequencies (approximately 0.98) within A. gambiae while ace-1(R) was not detected. Conclusions: This study provides useful data on the insecticide resistance profiles of malaria vector populations to better manage vector control. Our results highlight that, despite the high level of resistance, organophosphorus compounds and pyrethroids + PBO remain effective against the vectors.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
REPUBLIQUE DEMOCRATIQUE DU CONGO ; SUD KIVU
Localisation
Fonds IRD [F B010083353]
Identifiant IRD
fdi:010083353
