Abdallah F. auteur aut IRD Henriet E. auteur aut IRD Suet A. auteur aut IRD Arar A. auteur aut IRD Clemencon R. auteur aut IRD Malinge J. M. auteur aut IRD Lecellier Gael auteur aut IRD Baril P. auteur aut IRD Pichon C. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Psoriasis is a chronic inflammatory skin disease that is mediated by complex crosstalk between immune cells and keratinocytes (KCs). Emerging studies have showed a specific psoriatic microRNAs signature, in which miR-21 is one of the most upregulated and dynamic miRNAs. In this study, we focused our investigations on the passenger miR-21-3p strand, which is poorly studied in skin and in psoriasis pathogenesis. Here, we showed the upregulation of miR-21-3p in an IMQ-induced psoriasiform mouse model. This upregulation was correlated with IL-22 expression and functionality, both in vitro and in vivo, and it occurred via STAT3 and NF-kappa B signaling. We identified a network of differentially expressed genes involved in abnormal proliferation control and immune regulatory genes implicated in the molecular pathogenesis of psoriasis in response to miR-21-3p overexpression in KCs. These results were confirmed by functional assays that validated the proliferative potential of miR-21-3p. All these findings highlight the importance of miR-21-3p, an underestimated miRNA, in psoriasis and provide novel molecular targets for therapeutic purposes.</p> specialized IL-22 miR-21-5p miR-21-3p keratinocytes psoriasis proliferation 050 020 10 10 2547 [22 p.] 2021 https://www.documentation.ird.fr/hor/fdi:010083303 10.3390/cells10102547 [F B010083303] https://www.documentation.ird.fr/hor/fdi:010083303 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-12/010083303.pdf IRD - Base Horizon / Pleins textes 2021-12-03 2025-02-24 fdi:010083303 fre