%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Abdallah, F.
%A Henriet, E.
%A Suet, A.
%A Arar, A.
%A Clemencon, R.
%A Malinge, J. M.
%A Lecellier, Gael
%A Baril, P.
%A Pichon, C.
%T miR-21-3p/IL-22 axes are major drivers of psoriasis pathogenesis by modulating keratinocytes proliferation-survival balance and inflammatory response
%D 2021
%L fdi:010083303
%G ENG
%J Cells
%K IL-22 ; miR-21-5p ; miR-21-3p ; keratinocytes ; psoriasis ; proliferation
%M ISI:000713178400001
%N 10
%P 2547 [22 ]
%R 10.3390/cells10102547
%U https://www.documentation.ird.fr/hor/fdi:010083303
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-12/010083303.pdf
%V 10
%W Horizon (IRD)
%X Psoriasis is a chronic inflammatory skin disease that is mediated by complex crosstalk between immune cells and keratinocytes (KCs). Emerging studies have showed a specific psoriatic microRNAs signature, in which miR-21 is one of the most upregulated and dynamic miRNAs. In this study, we focused our investigations on the passenger miR-21-3p strand, which is poorly studied in skin and in psoriasis pathogenesis. Here, we showed the upregulation of miR-21-3p in an IMQ-induced psoriasiform mouse model. This upregulation was correlated with IL-22 expression and functionality, both in vitro and in vivo, and it occurred via STAT3 and NF-kappa B signaling. We identified a network of differentially expressed genes involved in abnormal proliferation control and immune regulatory genes implicated in the molecular pathogenesis of psoriasis in response to miR-21-3p overexpression in KCs. These results were confirmed by functional assays that validated the proliferative potential of miR-21-3p. All these findings highlight the importance of miR-21-3p, an underestimated miRNA, in psoriasis and provide novel molecular targets for therapeutic purposes.</p>
%$ 050 ; 020