@article{fdi:010083303,
  title = {mi{R}-21-3p/{IL}-22 axes are major drivers of psoriasis pathogenesis by modulating keratinocytes proliferation-survival balance and inflammatory response},
  author = {{A}bdallah, {F}. and {H}enriet, {E}. and {S}uet, {A}. and {A}rar, {A}. and {C}lemencon, {R}. and {M}alinge, {J}. {M}. and {L}ecellier, {G}ael and {B}aril, {P}. and {P}ichon, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}soriasis is a chronic inflammatory skin disease that is mediated by complex crosstalk between immune cells and keratinocytes ({KC}s). {E}merging studies have showed a specific psoriatic micro{RNA}s signature, in which mi{R}-21 is one of the most upregulated and dynamic mi{RNA}s. {I}n this study, we focused our investigations on the passenger mi{R}-21-3p strand, which is poorly studied in skin and in psoriasis pathogenesis. {H}ere, we showed the upregulation of mi{R}-21-3p in an {IMQ}-induced psoriasiform mouse model. {T}his upregulation was correlated with {IL}-22 expression and functionality, both in vitro and in vivo, and it occurred via {STAT}3 and {NF}-kappa {B} signaling. {W}e identified a network of differentially expressed genes involved in abnormal proliferation control and immune regulatory genes implicated in the molecular pathogenesis of psoriasis in response to mi{R}-21-3p overexpression in {KC}s. {T}hese results were confirmed by functional assays that validated the proliferative potential of mi{R}-21-3p. {A}ll these findings highlight the importance of mi{R}-21-3p, an underestimated mi{RNA}, in psoriasis and provide novel molecular targets for therapeutic purposes.</p>},
  keywords = {{IL}-22 ; mi{R}-21-5p ; mi{R}-21-3p ; keratinocytes ; psoriasis ; proliferation},
  booktitle = {},
  journal = {{C}ells},
  volume = {10},
  numero = {10},
  pages = {2547 [22 p.]},
  year = {2021},
  DOI = {10.3390/cells10102547},
  URL = {https://www.documentation.ird.fr/hor/fdi:010083303},
}