@article{fdi:010083227,
  title = {{P}re-conception serum ferritin concentrations are associated with metal concentrations in blood during pregnancy : a cohort study in {B}enin},
  author = {{D}avies, {S}. and {B}riand, {V}al{\'e}rie and {A}ccrombessi, {M}. and {F}ievet, {N}adine and {L}e {B}ot, {B}. and {D}urand, {S}. and {A}gbota, {G}ino and {Y}ovo, {E}. and {V}ianou, {B}. and {S}ossou, {D}. and {M}artin-{P}r{\'e}vel, {Y}ves and {M}assougbodji, {A}. and {C}ot, {M}ichel and {G}lorennec, {P}. and {B}odeau-{L}ivinec, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}ron deficiency is a common nutritional deficiency that impacts maternal health and fetal development and is also associated with increased uptake of toxic metals. {W}omen in sub-{S}aharan {A}frica are highly exposed to both iron deficiency and metals in the environment. {A}s research on the developmental origins of health and disease increasingly shows impacts of pre-conception maternal health on pregnancy and fetal health, these environmental exposures are of concern. {O}bjectives: {T}his study investigated the association between iron status pre-pregnancy and blood metal concentrations in the first trimester of pregnancy with potential implications for iron supplementation. {M}ethods: {P}re-conception and first trimester blood samples taken from 262 {B}eninese women were tested for serum ferritin, inflammation markers, manganese ({M}n), cadmium ({C}d), lead ({P}b), copper, zinc, selenium, mercury and arsenic. {A}ssociations between serum ferritin adjusted for inflammation and metal concentrations were analyzed using multivariate linear regression. {R}esults: {W}omen with iron deficiency before conception (13%) were more likely to remain iron deficient in the first trimester (4%) (adjusted {OR} = 41.2, 95%{CI} 6.2; 275.0) even within the context of routine iron supplementation during pregnancy. {L}ower pre-pregnancy serum ferritin concentrations were significantly related to higher concentrations of {M}n, {C}d and {P}b in the first trimester. {E}very 1% increase in serum ferritin concentration was associated with a 0.13% decrease in {M}n (adjusted beta = -0.13, 95%{CI} -0.18; -0.07), a 0.22% decrease in {C}d (adjusted beta = -0.22, 95%{CI} -0.28; -0.15) and a 0.06% decrease in {P}b concentration (adjusted beta = -0.06, 95%{CI} -0.12; -0.006). {D}iscussion: {T}hese results suggest that increasing iron stores prior to pregnancy may prevent excessive uptake of toxic concentrations of the metals {M}n, {C}d and {P}b and argue in favour of testing the effects of iron supplementation prior to pregnancy on metal concentrations.},
  keywords = {{I}ron deficiency ; {M}etals ; {E}nvironmental exposure ; {P}regnancy ; {P}re-conception ; {BENIN}},
  booktitle = {},
  journal = {{E}nvironmental {R}esearch},
  volume = {202},
  numero = {},
  pages = {111629 [9 ]},
  ISSN = {0013-9351},
  year = {2021},
  DOI = {10.1016/j.envres.2021.111629},
  URL = {https://www.documentation.ird.fr/hor/fdi:010083227},
}