@article{fdi:010083215,
  title = {{A}fucosylated {P}lasmodium falciparum-specific {I}g{G} is induced by infection but not by subunit vaccination},
  author = {{L}arsen, {M}. {D}. and {L}opez-{P}erez, {M}. and {D}ickson, {E}. {K}. and {A}mpomah, {P}. and {T}uikue {N}dam, {N}icaise and {N}outa, {J}. and {K}oeleman, {C}. {A}. {M}. and {E}derveen, {A}. {L}. {H}. and {M}ordmuller, {B}. and {S}alanti, {A}. and {N}ielsen, {M}. {A}. and {M}assougbodji, {A}. and van der {S}choot, {C}. {E}. and {O}fori, {M}. {F}. and {W}uhrer, {M}. and {H}viid, {L}. and {V}idarsson, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{H}ere, {L}arsen et al. describe differences in {F}c fucosylation of {P}. falciparum {P}f{EMP}1-specific {I}g{G} produced in response to natural infection versus {VAR}2{CSA}-type subunit vaccination, which leads to differences in the ability to induce {F}c gamma {RIII}a-dependent natural killer cell degranulation. {P}lasmodium falciparum erythrocyte membrane protein 1 ({P}f{EMP}1) family members mediate receptor- and tissue-specific sequestration of infected erythrocytes ({IE}s) in malaria. {A}ntibody responses are a central component of naturally acquired malaria immunity. {P}f{EMP}1-specific {I}g{G} likely protects by inhibiting {IE} sequestration and through {I}g{G}-{F}c {R}eceptor ({F}c gamma {R}) mediated phagocytosis and killing of antibody-opsonized {IE}s. {T}he affinity of afucosylated {I}g{G} to {F}c gamma {RIII}a is up to 40-fold higher than fucosylated {I}g{G}, resulting in enhanced antibody-dependent cellular cytotoxicity. {M}ost {I}g{G} in plasma is fully fucosylated, but afucosylated {I}g{G} is elicited in response to enveloped viruses and to paternal alloantigens during pregnancy. {H}ere we show that naturally acquired {P}f{EMP}1-specific {I}g{G} is strongly afucosylated in a stable and exposure-dependent manner, and efficiently induces {F}c gamma {RIII}a-dependent natural killer ({NK}) cell degranulation. {I}n contrast, immunization with a subunit {P}f{EMP}1 ({VAR}2{CSA}) vaccine results in fully fucosylated specific {I}g{G}. {T}hese results have implications for understanding protective natural- and vaccine-induced immunity to malaria.},
  keywords = {{GHANA}},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {12},
  numero = {1},
  pages = {5838 [10 p.]},
  year = {2021},
  DOI = {10.1038/s41467-021-26118-w},
  URL = {https://www.documentation.ird.fr/hor/fdi:010083215},
}