Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Pathogens 1127 [23 ] Aedes aegypti ABC transporters immunity arboviruses dengue virus 2021 fdi:010083186 ENG Pathogens ISI:000701830800001 9 10.3390/pathogens10091127 https://www.documentation.ird.fr/hor/fdi:010083186 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-11/010083186.pdf 10 Horizon (IRD) Aedes aegypti acts as a vector for several arboviral diseases that impose a major socio-economic burden. Moreover, the absence of a vaccine against these diseases and drug resistance in mosquitoes necessitates the development of new control strategies for vector-borne diseases. ABC transporters that play a vital role in immunity and other cellular processes in different organisms may act as non-canonical immune molecules against arboviruses, however, their role in mosquito immunity remains unexplored. This study comprehensively analyzed various genetic features of putative ABC transporters and classified them into A-H subfamilies based on their evolutionary relationships. Existing RNA-sequencing data analysis indicated higher expression of cytosolic ABC transporter genes (E & F Subfamily) throughout the mosquito development, while members of other subfamilies exhibited tissue and time-specific expression. Furthermore, comparative gene expression analysis from the microarray dataset of mosquito infected with dengue, yellow fever and West Nile viruses revealed 31 commonly expressed ABC transporters suggesting a potentially conserved transcriptomic signature of arboviral infection. Among these, only a few transporters of ABCA, ABCC and ABCF subfamily were upregulated, while most were downregulated. This indicates the possible involvement of ABC transporters in mosquito immunity. 052 ; 020 UR224 Inde