%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Kumar, V.
%A Garg, S.
%A Gupta, L.
%A Gupta, K.
%A Diagne, C. T.
%A Missé, Dorothée
%A Pompon, Julien
%A Kumar, S.
%A Saxena, V.
%T Delineating the role of Aedes aegypti ABC transporter gene family during mosquito development and arboviral infection via transcriptome analyses
%D 2021
%L fdi:010083186
%G ENG
%J Pathogens
%K Aedes aegypti ; ABC transporters ; immunity ; arboviruses ; dengue virus
%M ISI:000701830800001
%N 9
%P 1127 [23 ]
%R 10.3390/pathogens10091127
%U https://www.documentation.ird.fr/hor/fdi:010083186
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-11/010083186.pdf
%V 10
%W Horizon (IRD)
%X Aedes aegypti acts as a vector for several arboviral diseases that impose a major socio-economic burden. Moreover, the absence of a vaccine against these diseases and drug resistance in mosquitoes necessitates the development of new control strategies for vector-borne diseases. ABC transporters that play a vital role in immunity and other cellular processes in different organisms may act as non-canonical immune molecules against arboviruses, however, their role in mosquito immunity remains unexplored. This study comprehensively analyzed various genetic features of putative ABC transporters and classified them into A-H subfamilies based on their evolutionary relationships. Existing RNA-sequencing data analysis indicated higher expression of cytosolic ABC transporter genes (E & F Subfamily) throughout the mosquito development, while members of other subfamilies exhibited tissue and time-specific expression. Furthermore, comparative gene expression analysis from the microarray dataset of mosquito infected with dengue, yellow fever and West Nile viruses revealed 31 commonly expressed ABC transporters suggesting a potentially conserved transcriptomic signature of arboviral infection. Among these, only a few transporters of ABCA, ABCC and ABCF subfamily were upregulated, while most were downregulated. This indicates the possible involvement of ABC transporters in mosquito immunity.
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