Delineating the role of Aedes aegypti ABC transporter gene family during mosquito development and arboviral infection via transcriptome analyses Kumar, V. Garg, S. Gupta, L. Gupta, K. Diagne, C. T. /Missé, Dorothée /Pompon, Julien Kumar, S. Saxena, V. Aedes aegypti ABC transporters immunity arboviruses dengue virus Aedes aegypti acts as a vector for several arboviral diseases that impose a major socio-economic burden. Moreover, the absence of a vaccine against these diseases and drug resistance in mosquitoes necessitates the development of new control strategies for vector-borne diseases. ABC transporters that play a vital role in immunity and other cellular processes in different organisms may act as non-canonical immune molecules against arboviruses, however, their role in mosquito immunity remains unexplored. This study comprehensively analyzed various genetic features of putative ABC transporters and classified them into A-H subfamilies based on their evolutionary relationships. Existing RNA-sequencing data analysis indicated higher expression of cytosolic ABC transporter genes (E & F Subfamily) throughout the mosquito development, while members of other subfamilies exhibited tissue and time-specific expression. Furthermore, comparative gene expression analysis from the microarray dataset of mosquito infected with dengue, yellow fever and West Nile viruses revealed 31 commonly expressed ABC transporters suggesting a potentially conserved transcriptomic signature of arboviral infection. Among these, only a few transporters of ABCA, ABCC and ABCF subfamily were upregulated, while most were downregulated. This indicates the possible involvement of ABC transporters in mosquito immunity. 2021 text https://www.documentation.ird.fr/hor/fdi:010083186 fdi:010083186 Kumar V., Garg S., Gupta L., Gupta K., Diagne C. T., Missé Dorothée, Pompon Julien, Kumar S., Saxena V.. Delineating the role of Aedes aegypti ABC transporter gene family during mosquito development and arboviral infection via transcriptome analyses. 2021, 10 (9), 1127 [23 ] EN