@article{fdi:010083186,
  title = {{D}elineating the role of {A}edes aegypti {ABC} transporter gene family during mosquito development and arboviral infection via transcriptome analyses},
  author = {{K}umar, {V}. and {G}arg, {S}. and {G}upta, {L}. and {G}upta, {K}. and {D}iagne, {C}. {T}. and {M}iss{\'e}, {D}oroth{\'e}e and {P}ompon, {J}ulien and {K}umar, {S}. and {S}axena, {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}edes aegypti acts as a vector for several arboviral diseases that impose a major socio-economic burden. {M}oreover, the absence of a vaccine against these diseases and drug resistance in mosquitoes necessitates the development of new control strategies for vector-borne diseases. {ABC} transporters that play a vital role in immunity and other cellular processes in different organisms may act as non-canonical immune molecules against arboviruses, however, their role in mosquito immunity remains unexplored. {T}his study comprehensively analyzed various genetic features of putative {ABC} transporters and classified them into {A}-{H} subfamilies based on their evolutionary relationships. {E}xisting {RNA}-sequencing data analysis indicated higher expression of cytosolic {ABC} transporter genes ({E} & {F} {S}ubfamily) throughout the mosquito development, while members of other subfamilies exhibited tissue and time-specific expression. {F}urthermore, comparative gene expression analysis from the microarray dataset of mosquito infected with dengue, yellow fever and {W}est {N}ile viruses revealed 31 commonly expressed {ABC} transporters suggesting a potentially conserved transcriptomic signature of arboviral infection. {A}mong these, only a few transporters of {ABCA}, {ABCC} and {ABCF} subfamily were upregulated, while most were downregulated. {T}his indicates the possible involvement of {ABC} transporters in mosquito immunity.},
  keywords = {{A}edes aegypti ; {ABC} transporters ; immunity ; arboviruses ; dengue virus},
  booktitle = {},
  journal = {{P}athogens},
  volume = {10},
  numero = {9},
  pages = {1127 [23 ]},
  year = {2021},
  DOI = {10.3390/pathogens10091127},
  URL = {https://www.documentation.ird.fr/hor/fdi:010083186},
}