Guemouri Sayeh auteur aut IRD Courtois L. auteur aut IRD Mama A. auteur aut IRD Rouas B. auteur aut IRD Braga G. N. auteur aut IRD Accrombessi M. auteur aut IRD Massougbodji A. auteur aut IRD Ding X. C. auteur aut IRD Tuikue Ndam Nicaise auteur aut IRD Fievet Nadine auteur aut IRD Briand Valérie auteur aut IRD text journalArticle eng text/pdf reformatted digital access Background. Malaria infections in the first trimester of pregnancy are frequent and deleterious for both mother and child health. To investigate if these early infections are newly acquired or already present in the host, we assessed whether parasites detected before pregnancy and those detected in early pregnancy are the same infection. Methods. We used data from the preconceptional "RECIPAL" study (Benin, 2014-2017). Sixty-three pregnant women of 411 included who had a malaria infection detected by quantitative polymerase chain reaction both before pregnancy and at the first antenatal care (ANC) visit were selected for this study. Two highly polymorphic markers, msp-2 and glurp, and a fragment-analysis method were used to enumerate the Plasmodium falciparum genotypes and to quantify their proportions within isolates. An infection was considered as persistent when identical rasp-2 and glurp genotypes were found in the corresponding prepregnancy and early-pregnancy samples. Results. The median time between the 2 malaria screenings was 3 months. The median gestational age at the first ANC visit was 6.4 weeks. Most infections before pregnancy were submicroscopic infections. Based on both msp-2 and glurp genotyping, the infection was similar before and in early pregnancy in 46% (29/63) of cases. Conclusions. Almost half of P. falciparum infections detected in the first trimester originate before pregnancy. Protecting young women from malaria infection before pregnancy might reduce the prevalence of malaria in early pregnancy and its related poor maternal and birth outcomes. specialized malaria pregnancy Africa genotyping techniques polymerase chain reaction BENIN 050 052 020 73 2 E355-E361 2021 1058-4838 https://www.documentation.ird.fr/hor/fdi:010083135 10.1093/cid/ciaa841 1058-4838 [F B010083135] https://www.documentation.ird.fr/hor/fdi:010083135 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-11/010083135.pdf IRD - Base Horizon / Pleins textes 2021-11-10 2025-02-24 fdi:010083135 fre