@article{fdi:010083135,
  title = {{A} genotyping study in {B}enin comparing the carriage of {P}lasmodium falciparum infections before pregnancy and in early pregnancy : story of a persistent infection},
  author = {{G}uemouri, {S}ayeh and {C}ourtois, {L}. and {M}ama, {A}. and {R}ouas, {B}. and {B}raga, {G}. {N}. and {A}ccrombessi, {M}. and {M}assougbodji, {A}. and {D}ing, {X}. {C}. and {T}uikue {N}dam, {N}icaise and {F}ievet, {N}adine and {B}riand, {V}al{\'e}rie},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {M}alaria infections in the first trimester of pregnancy are frequent and deleterious for both mother and child health. {T}o investigate if these early infections are newly acquired or already present in the host, we assessed whether parasites detected before pregnancy and those detected in early pregnancy are the same infection. {M}ethods. {W}e used data from the preconceptional "{RECIPAL}" study ({B}enin, 2014-2017). {S}ixty-three pregnant women of 411 included who had a malaria infection detected by quantitative polymerase chain reaction both before pregnancy and at the first antenatal care ({ANC}) visit were selected for this study. {T}wo highly polymorphic markers, msp-2 and glurp, and a fragment-analysis method were used to enumerate the {P}lasmodium falciparum genotypes and to quantify their proportions within isolates. {A}n infection was considered as persistent when identical rasp-2 and glurp genotypes were found in the corresponding prepregnancy and early-pregnancy samples. {R}esults. {T}he median time between the 2 malaria screenings was 3 months. {T}he median gestational age at the first {ANC} visit was 6.4 weeks. {M}ost infections before pregnancy were submicroscopic infections. {B}ased on both msp-2 and glurp genotyping, the infection was similar before and in early pregnancy in 46% (29/63) of cases. {C}onclusions. {A}lmost half of {P}. falciparum infections detected in the first trimester originate before pregnancy. {P}rotecting young women from malaria infection before pregnancy might reduce the prevalence of malaria in early pregnancy and its related poor maternal and birth outcomes.},
  keywords = {malaria ; pregnancy ; {A}frica ; genotyping techniques ; polymerase chain reaction ; {BENIN}},
  booktitle = {},
  journal = {{C}linical {I}nfectious {D}iseases},
  volume = {73},
  numero = {2},
  pages = {{E}355--{E}361},
  ISSN = {1058-4838},
  year = {2021},
  DOI = {10.1093/cid/ciaa841},
  URL = {https://www.documentation.ird.fr/hor/fdi:010083135},
}