@article{fdi:010082832,
  title = {{B}ridging tumorigenesis and therapy resistance with a non-{D}arwinian and non-{L}amarckian mechanism of adaptive evolution},
  author = {{C}atania, {F}. and {U}jvari, {B}. and {R}oche, {B}enjamin and {C}app, {J}. {P}. and {T}homas, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}lthough neo-{D}arwinian (and less often {L}amarckian) dynamics are regularly invoked to interpret cancer's multifarious molecular profiles, they shine little light on how tumorigenesis unfolds and often fail to fully capture the frequency and breadth of resistance mechanisms. {T}his uncertainty frames one of the most problematic gaps between science and practice in modern times. {H}ere, we offer a theory of adaptive cancer evolution, which builds on a molecular mechanism that lies outside neo-{D}arwinian and {L}amarckian schemes. {T}his mechanism coherently integrates non-genetic and genetic changes, ecological and evolutionary time scales, and shifts the spotlight away from positive selection towards purifying selection, genetic drift, and the creative-disruptive power of environmental change. {T}he surprisingly simple use-it or lose-it rationale of the proposed theory can help predict molecular dynamics during tumorigenesis. {I}t also provides simple rules of thumb that should help improve therapeutic approaches in cancer.},
  keywords = {tumor evolution ; adaptation ; cell growth ; stress response ; natural selection ; environment ; cancer therapy},
  booktitle = {},
  journal = {{F}rontiers in {O}ncology},
  volume = {11},
  numero = {},
  pages = {732081 [15 ]},
  ISSN = {2234-943{X}},
  year = {2021},
  DOI = {10.3389/fonc.2021.732081},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082832},
}