@article{fdi:010082826,
  title = {{C}ontrasting effects of the alkaloid ricinine on the capacity of {A}nopheles gambiae and {A}nopheles coluzzii to transmit {P}lasmodium falciparum},
  author = {{H}ien, {D}fds and {P}are, {P}. {S}. {L}. and {C}ooper, {A}. and {K}oama, {B}. {K}. and {G}uissou, {E}. and {Y}ameogo, {K}. {B}. and {Y}erbanga, {R}. {S}. and {F}arrell, {I}. {W}. and {O}uedraogo, {J}. {B}. and {G}nankine, {O}. and {I}gnell, {R}. and {C}ohuet, {A}nna and {D}abire, {R}. {K}. and {S}tevenson, {P}. {C}. and {L}ef{\`e}vre, {T}hierry},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {B}esides feeding on blood, females of the malaria vector {A}nopheles gambiae sensu lato readily feed on natural sources of plant sugars. {T}he impact of toxic secondary phytochemicals contained in plant-derived sugars on mosquito physiology and the development of {P}lasmodium parasites remains elusive. {T}he focus of this study was to explore the influence of the alkaloid ricinine, found in the nectar of the castor bean {R}icinus communis, on the ability of mosquitoes to transmit {P}lasmodium falciparum. {M}ethods: {F}emales of {A}nopheles gambiae and its sibling species {A}nopheles coluzzii were exposed to ricinine through sugar feeding assays to assess the effect of this phytochemical on mosquito survival, level of {P}. falciparum infection and growth rate of the parasite. {R}esults: {R}icinine induced a significant reduction in the longevity of both {A}nopheles species. {R}icinine caused acceleration in the parasite growth rate with an earlier invasion of the salivary glands in both species. {A}t a concentration of 0.04 g l(-1) in {A}n. coluzzii, ricinine had no effect on mosquito infection, while 0.08 g l(-1) ricinine-5% glucose solution induced a 14% increase in {A}n. gambiae infection rate. {C}onclusions: {O}verall, our findings reveal that consumption of certain nectar phytochemicals can have unexpected and contrasting effects on key phenotypic traits that govern the intensity of malaria transmission. {F}urther studies will be required before concluding on the putative role of ricinine as a novel control agent, including the development of ricinine-based toxic and transmission-blocking sugar baits. {T}esting other secondary phytochemicals in plant nectar will provide a broader understanding of the impact which plants can have on the transmission of vector-borne diseases.},
  keywords = {{P}lasmodium falciparum ; {A}nopheles coluzzii ; {A}nopheles gambiae ; {R}icinine ; {M}alaria transmission ; {T}ransmission-blocking strategies},
  booktitle = {},
  journal = {{P}arasites and {V}ectors},
  volume = {14},
  numero = {1},
  pages = {479 [11 p.]},
  ISSN = {1756-3305},
  year = {2021},
  DOI = {10.1186/s13071-021-04992-z},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082826},
}