@article{fdi:010082810,
  title = {{R}eplicative fitness of a {SARS}-{C}o{V}-2 20{I}/501{Y}.{V}1 variant from lineage {B}.1.1.7 in human reconstituted bronchial epithelium},
  author = {{T}ouret, {F}. and {L}uciani, {L}. and {B}aronti, {C}{\'e}cile and {C}ochin, {M}. and {D}riouich, {J}. {S}. and {G}illes, {M}agali and {T}hirion, {L}aurence and {N}ougair{\`e}de, {A}. and {L}amballerie, {X}. de},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ince its emergence in 2019, circulating populations of the new corona virus ({C}o{V}) continuously acquired genetic diversity. {A}t the end of 2020, a variant named 20{I}/501{Y}.{V}1 (lineage {B}.1.1.7) emerged and replaced other circulating strains in several regions. {T}his phenomenon has been poorly associated with biological evidence that this variant and the original strain exhibit different phenotypic characteristics. {H}ere, we analyze the replication ability of this new variant in different cellular models using for comparison an ancestral {D}614{G} {E}uropean strain (lineage {B}1). {R}esults from comparative replication kinetics experiments in vitro and in a human reconstituted bronchial epithelium showed no difference. {H}owever, when both viruses were put in competition in human reconstituted bronchial epithelium, the 20{I}/501{Y}.{V}1 variant outcompeted the ancestral strain. {A}ll together, these findings demonstrate that this new variant replicates more efficiently and may contribute to a better understanding of the progressive replacement of circulating strains by the severe acute respiratory {C}o{V}-2 ({SARS}-{C}o{V}-2) 20{I}/501{Y}.{V}1 variant. {IMPORTANCE} {T}he emergence of several {SARS}-{C}o{V}-2 variants raised numerous questions concerning the future course of the pandemic. {W}e are currently observing a replacement of the circulating viruses by the variant from the {U}nited {K}ingdom known as 20{I}/501{Y}.{V}1, from the {B}.1.1.7 lineage, but there is little biological evidence that this new variant exhibits a different phenotype. {I}n the present study, we used different cellular models to assess the replication ability of the 20{I}/501{Y}.{V}1 variant. {O}ur results showed that this variant replicates more efficiently in human reconstituted bronchial epithelium, which may explain why it spreads so rapidly in human populations.},
  keywords = {20{I}/501{Y}.{V}1 ; {B}.1.1.7 ; {SARS}-{C}o{V}-2 ; ex vivo ; in vitro ; replicative ; fitness ; variant},
  booktitle = {},
  journal = {{M}bio},
  volume = {12},
  numero = {4},
  pages = {e00850--21 [4 ]},
  ISSN = {2150-7511},
  year = {2021},
  DOI = {10.1128/m{B}io.00850-21},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082810},
}