@article{fdi:010082799,
  title = {{C}otrimoxazole versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in {HIV}-infected pregnant women in {B}angui, {C}entral {A}frican {R}epublic : a pragmatic randomised controlled trial},
  author = {{M}anirakiza, {A}. and {T}ondeur, {L}. and {K}etta, {M}. {Y}. {B}. and {S}epou, {A}. and {S}erdouma, {E}. and {G}ondje, {S}. and {B}ata, {G}. {G}. {B}. and {B}oulay, {A}. and {M}oyen, {J}. {M}. and {S}akanga, {O}. and {L}e-{F}ouler, {L}. and {K}azanji, {M}. and {B}riand, {V}al{\'e}rie and {L}ombart, {J}. {P}. and {V}ray, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective {T}he main objective of the {MACOMBA} ({M}aternity and {C}ontrol of {M}alaria-{HIV} co-infection in {B}angui) trial was to show that cotrimoxazole ({CTX}) is more effective than sulphadoxine-pyremethamine-{IPT}p ({IPT}p-{SP}) to prevent placental malaria infection (primary end point) among {HIV}-positive pregnant women with a {CD}4+ count >= 350 cells/mm(3) in {B}angui, {CAR}. {M}ethods {MACOMBA} is a multicentre, open-label randomised trial conducted in four maternity hospitals in {B}angui. {B}etween 2013 and 2017, 193 women were randomised and 112 (59 and 53 in {CTX} and {IPT}p-{SP} arms, respectively) were assessed for placental infection defined by microscopic parasitaemia or {PCR}. {R}esults {T}hirteen women had a placental infection: five in the {CTX} arm (one by microscopic placental parasitaemia and four by {PCR}) and eight by {PCR} in the {SP}-{IPT}p (8.5% vs. 15.1%, p = 0.28). {T}he percentage of newborns with low birthweight (<2500 g) did not differ statistically between the two arms. {S}elf-reported compliance to {CTX} prophylaxis was good. {T}here was a low overall rate of adverse events in both arms. {C}onclusion {A}lthough our results do not allow us to conclude that {CTX} is more effective, drug safety and good compliance among women with this treatment favour its widespread use among {HIV}-infected pregnant women, as currently recommended by {WHO}.},
  keywords = {malaria ; pregnant women ; prophylaxis {HIV} ; {CENTRAFRIQUE} ; {BANGUI}},
  booktitle = {},
  journal = {{T}ropical {M}edicine and {I}nternational {H}ealth},
  volume = {26},
  numero = {10},
  pages = {1314--1323},
  ISSN = {1360-2276},
  year = {2021},
  DOI = {10.1111/tmi.13668},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082799},
}